Movement-Disorders Focused Clinical Neuroscience Training for Psychiatry Residents: A Competency-Based Medical Education Model
Objective: To illustrate a novel educational program model that can train psychiatrists to develop competencies in caring for patients with movement disorders such as Parkinson's…Patient engagement in Parkinson’s research: Exploring stakeholder perspectives
Objective: The aim of this project was to explore patient engagement in Parkinson’s research in Canada from the perspectives of different stakeholders, and to identify…Aquatic Interval Training in Individuals with Parkinson’s Disease: Can It Improve Gait?
Objective: To identify changes in gait speed and gait-related activities after an aquatic interval training physiotherapy program in individuals with PD. Background: Parkinson's disease (PD)…Lewy Pathology in the Peripheral Nervous System of SNCA Duplication
Objective: This study aimed to investigate the degree, distribution, and biochemical profile of phosphorylated α-synuclein (p-α-syn) in the peripheral nervous system of patients with SNCA…Wearable-based digital measures from the Verily Study Watch can detect concurrent symptomatic treatment effects in a subset of early-stage Parkinson’s disease ORCHESTRA trial participants
Objective: To investigate the effect of concurrent symptomatic treatment (ST) on digital measures collected in ORCHESTRA (NCT04658186). Background: Minzasolmin is an oral small molecule that…A Double-Blind, Cross-Over Pilot Study Comparing Adaptive Deep Brain Stimulation (aDBS) to Conventional DBS in Parkinson’s Disease
Objective: To compare the efficacy of adaptive deep brain stimulation (aDBS) to conventional DBS (cDBS) in Parkinson’s disease through a double-blind, cross-over pilot study. Background:…Unilateral focused ultrasound subthalamotomy in early Parkinson’s disease: randomized-controlled trial protocol
Objective: To describe the protocol of a multicenter, prospective, randomized controlled trial (EarlyFocus II) which evaluates the efficacy and safety of unilateral magnetic resonance-guided focused…Efficacy of ND0612 in Patients at Different Stages of Disease Severity: Subgroup-Analyses From a Randomized, Active-Controlled Study in People With Parkinson’s Disease Experiencing Motor Fluctuations
Objective: To evaluate the efficacy of investigational ND0612 in reducing motor fluctuations in patients with Parkinson’s disease (PD) at different stages of disease and/or symptom…Effect of Allogeneic Bone-Marrow Derived Mesenchymal Stem Cell Therapy on Quality of Life in Patients with Parkinson’s Disease
Objective: To assess the impact of intravenous (IV) allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) infusions on the quality of life (QoL) of patients with…Targeting inflammation and autophagy: a dual-inhibition strategy to reduce α-synuclein pathology in GBA1-associated Parkinson’s disease
Objective: To assess the effects of combined inhibition of mTOR (autophagy regulator) and STING (inflammation regulator) on α-synuclein phosphorylation, tyrosine hydroxylase expression, and lysosphingolipid levels in…
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