Neuroprotective Role of Diosgenin-Loaded Lipid Nanoparticles for Parkinson’s Disease: Pharmacokinetic and Pharmacodynamic Insights
Objective: To develop, optimize, and evaluate diosgenin-loaded solid lipid nanoparticles (DG-SLNs) and nanostructured lipid carriers (DG-NLCs) incorporated into hydrogel formulations (DG-SLN-C and DG-NLC-C) for improved…Gait Assessment for Parkinson’s Disease Patients Utilizing a Pressure Sensor Insole System
Objective: This study is an extension of a pilot study performed in 2021 and aims to investigate the clinical significance of exploiting wearable sensors such…AI-Driven Wearable Sensor Monitoring for Improved Assessment of Advanced Treatment Readiness in Parkinson’s Disease – A pilot study
Objective: This study evaluated the potential of wearables and AI-driven continuous monitoring to assess motor symptoms in Parkinson’s disease (PD). We aimed to determine their…Hospitalization Safety in Parkinson’s Disease (PD): Baseline Outcomes Tracked over 1 Year and a Multi-disciplinary Program to Improve Care
Objective: To report baseline hospitalization outcomes in PD and the development of a comprehensive program for quality improvement. Background: Hospitalization is common in PD and…Movement-Disorders Focused Clinical Neuroscience Training for Psychiatry Residents: A Competency-Based Medical Education Model
Objective: To illustrate a novel educational program model that can train psychiatrists to develop competencies in caring for patients with movement disorders such as Parkinson's…Patient engagement in Parkinson’s research: Exploring stakeholder perspectives
Objective: The aim of this project was to explore patient engagement in Parkinson’s research in Canada from the perspectives of different stakeholders, and to identify…Aquatic Interval Training in Individuals with Parkinson’s Disease: Can It Improve Gait?
Objective: To identify changes in gait speed and gait-related activities after an aquatic interval training physiotherapy program in individuals with PD. Background: Parkinson's disease (PD)…Lewy Pathology in the Peripheral Nervous System of SNCA Duplication
Objective: This study aimed to investigate the degree, distribution, and biochemical profile of phosphorylated α-synuclein (p-α-syn) in the peripheral nervous system of patients with SNCA…Wearable-based digital measures from the Verily Study Watch can detect concurrent symptomatic treatment effects in a subset of early-stage Parkinson’s disease ORCHESTRA trial participants
Objective: To investigate the effect of concurrent symptomatic treatment (ST) on digital measures collected in ORCHESTRA (NCT04658186). Background: Minzasolmin is an oral small molecule that…A Double-Blind, Cross-Over Pilot Study Comparing Adaptive Deep Brain Stimulation (aDBS) to Conventional DBS in Parkinson’s Disease
Objective: To compare the efficacy of adaptive deep brain stimulation (aDBS) to conventional DBS (cDBS) in Parkinson’s disease through a double-blind, cross-over pilot study. Background:…
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