Differential Effect of alpha-Synuclein on Mitochondrial Morphology in PD and MSA
Objective: In this study, we investigated the morphology of mitochondria and localization of alpha-synuclein as driven by alpha-synuclein isolated from PD and MSA brain-derived tissue.…Neuronal DJ-1 regulates microglia activation via ADAM10-mediated CX3CL1 secretion
Objective: DJ-1, also known as Parkinson's disease protein 7 (PARK7), is a multifunctional protein that is important in regulating oxidative stress and neuroprotection. Background: The…Apolipoprotein E ɛ4-allele and Amygdala Atrophy in Parkinson’s Disease: A Preliminary Longitudinal Analysis from the ONDRI Cohort
Objective: To investigate the association of apolipoprotein E ɛ4-allele (APOE-ε4) with amygdala volumes longitudinally in Parkinson’s disease (PD). Background: APOE-ε4 is a genetic risk factor…Unveiling the Molecular Mechanism of Polydatin in Ameliorating Parkinson’s Disease via the DRD2/CRYAB/NF-κB Axis in Astrocytes and Exploring Cell Therapy Strategies
Objective: Define polydatin's therapeutic mechanism targeting astrocyte-mediated neuroinflammation in Parkinson's disease (PD) and assess combinatorial efficacy with dopamine progenitor transplantation. Background: PD progression involves substantia…Characterising Peripheral Innate Immune Cell Infiltration into the Brain in Parkinson’s Disease
Objective: To characterise the infiltration of peripheral innate immune cells (NK cells, monocytes and neutrophils) into the brain in Parkinson’s disease (PD) and to investigate…Bayesian Re-Analysis of Phase I and II Subthalamic Nucleus Perfusion Changes Following Mesenchymal Stem Cell Infusion in Parkinson’s Disease
Objective: To compare subthalamic nucleus (STN) perfusion changes following mesenchymal stem cell (MSC) infusion in Parkinson’s disease (PD) using Bayesian methods in both Phase I…Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing
Objective: Aim of this study is to describe specific alterations in comprehending syntactically complex sentences in patients with Lewy body diseases (LBDs) that already have…Diffusion MRI Changes Linked to α-Synuclein Seed Amplification Status in Parkinson’s Disease
Objective: To compare free-water (FW) imaging in individuals with Parkinson’s disease (PD), with positive vs. negative cerebrospinal fluid (CSF) α-synuclein seed amplification assay (SAA) status.…Genotypic and phenotypic characterization of the population living with Parkinson disease in the northwest region of Argentina
Objective: To conduct a demographic, phenotypic, and genotypic characterization of Parkinson's disease (PD) patients in northwest Argentina. Background: Despite PD's widespread nature, most genetic studies…Deep phenotyping of Parkinson‘s disease patients with the RAB32 Ser71Arg pathogenic variant and MDSGene literature review
Objective: To evaluate patients with PD and unaffected carriers of the pathogenic variant RAB32 p.Ser71Arg using a multimodal approach to gain insight into genotype-phenotype relationships…
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