Motor Fluctuations in Parkinsons Disease and their Correction
Objective: To evaluate the frequency of motor fluctuations in patients with Parkinson's disease and to study the effectiveness of methods modifying the course of the…Comprehensive Multi-Platform Proteomic Analysis Identifies Novel Biomarkers for Parkinson’s Disease Diagnosis and Progression Monitoring
Objective: To replicate existing and identify novel protein biomarkers for PD diagnosis and progression. Background: Parkinson's disease (PD) lacks reliable biomarkers for early diagnosis and…Neutrophil Extracellular Traps Reveal Novel Inflammatory Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: This cross-sectional study investigates neutrophil extracellular trap (NET) activation in Parkinson’s disease (PD) and multiple system atrophy (MSA) by quantifying plasma levels of NET-associated…Phase 1 and 1b Pharmacodynamic Data Support Central Modulation of Lysosomal Pathways With BIIB122/DNL151, a LRRK2 Kinase Inhibitor: Insights for the LUMA Trial
Objective: Evaluate the effects of BIIB122/DNL151 treatment on CSF levels of pRab10, a biomarker of CNS LRRK2 modulation, in a Phase 1 study in healthy…Identification of Rigidity in Parkinson’s Disease Using Wearable Technology
Objective: To evaluate the capacity of upper limb kinematic measures, collected using wearable technology, in (a) capturing clinical rigidity in Parkinson’s disease (PD) and (b)…Virtual Reality to Assess for Digital Biomarkers of Visual Hallucinations in Parkinson’s Disease
Objective: Use a novel virtual reality (VR) protocol to evaluate for potential digital biomarkers of visual hallucinations (VH) in Parkinson’s Disease (PD). Background: VH are common…Characterization of neuronal exosomes purified from plasma of Parkinson’s Disease Chilean patients
Objective: The diagnosis of PD is usually late and has only palliative treatments that seek to slow the progression of motor symptoms. These characteristics make…Sex Differences for Autopsy-Confirmed Prodromal Lewy Body Dementia
Objective: To assess sex differences in prodromal Lewy body dementia (LBD) compared to Alzheimer’s disease (AD) Background: Identifying LBD at the prodromal stage can provide…Cognitive Biases in Movement Disorders: Implications for Clinical Decision-Making and Patient Perception of Symptoms
Objective: To explore how cognitive biases affect decision-making in patients with movement disorders, including misjudgments in symptom perception, risk-taking in treatment decisions and adherence to…Modeling Dementia in Patients with Parkinson’s Disease Years After DBS
Objective: The objective of this study is to identify pre-operative cognitive characteristics of patients who are candidates for deep brain stimulation surgery that may contribute…
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