Quality of Life of Parkinson’s Disease Patients in the Thai Population: A Cross-Sectional Analysis
Objective: Primary: To assess QoL in PD patients at the Neurological Institute of Thailand (NIT).Secondary: To identify clinical factors associated with QoL. Background: Parkinson’s disease…Evaluating the Efficacy of Home-Based Exercise Interventions for Individuals with Mild to Moderate Parkinson’s Disease: A Systematic Review
Objective: To systematically evaluate the effectiveness of HBEI on motor symptoms, balance, and overall well-being in individuals with mild to moderate PD, providing insights into…LRRK2 I1371V Mutation Induces ER Stress, Mitochondrial Dysfunction, and Impaired Mitophagy in Parkinson’s Disease Astrocytes
Objective: This study examines the pathogenic effect of the LRRK2 I1371V mutation on mitochondrial dysfunction, as a result of ER calcium dysregulation, and impaired mitophagy…Metabolomic Profiling in an Egyptian Cohort Reveals Altered Phenylalanine Metabolism and Suggests a Role for Trans-Cinnamate in Parkinson Disease
Objective: Investigate the associated metabolic changes in PD via a comprehensive metabolic analysis with a focus on phenylalanine (dopamine precursor) metabolism and its impact on…Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy
Objective: In the present study, we aim to counteract regulatory and transcriptional modifiers of autophagy to enhance neuroprotective proteostasis and rescue alpha-synuclein (asyn) toxicity in…Amygdala-predominant Lewy Body Disease is a Lens for Understanding Pathogenesis and the Alpha-synuclein Seeding Assay in Human Postmortem Brain
Objective: To map alpha-synuclein (asyn) and tau markers in amygdala-predominant Lewy body disease (AP-LBD), identifying spread pathways and vulnerable cell populations. Background: LBD often co-occurs…The differential transcriptomic signatures of substantia nigra in Parkinson disease and Multiple system atrophy
Objective: To investigate transcriptomic signatures of Parkinson's disease (PD) and the Parkinsonian subtype of Multiple System Atrophy (MSA-P) in the substantia nigra pars compacta (SNpc).…Dopamine Transporter Imaging as a Predictor of Functional Outcomes in Parkinson’s Disease
Objective: To evaluate the prognostic value of dopamine transporter (DAT) imaging in predicting future disability, as well as motor and non-motor burden, in Parkinson’s disease…Exploring local gyrification index to understand Parkinson’s disease with mild cognitive impairment
Objective: To investigate correlations between local gyrification index (LGI) and neuropsychological variables in participants with Parkinson's disease (PD) experiencing mild cognitive impairment (PD-MCI). Background: PD…Robust Computation of Subcortical Functional Connectivity Guided by Quantitative Susceptibility Mapping: An Application in Parkinson’s Disease Diagnosis
Objective: In this study, we aimed to introduce and validate a method that incorporates quantitative susceptibility mapping (QSM) into the rs-fMRI analytical pipeline to achieve…
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