Sex-Stratified Multi-Omic Integration Identifies Sexually Dimorphic Molecular Targets in Parkinson’s Disease
Objective: To identify sex-specific causal proteins and biological pathways underlying the sexual dimorphism of Parkinson's disease (PD) through an integrative multi-omics framework. Background: PD exhibits…Evaluation of Sleep Parameters in Parkinson’s Disease According to Disease Duration Using Ambulatory Circadian Monitoring
Objective: To evaluate clinical characteristics and objective sleep parameters in patients with Parkinson’s disease (PD) according to disease duration (<6 years versus >6 years). Background: Sleep disturbances are…Restoring Dopaminergic Function: iPSC-derived MSCs Show Therapeutic Promise in Parkinson’s Disease Rat Model
Objective: This study looked into the therapeutic potential of human induced pluripotent stem cell derived mesenchymal stromal cells (iMSCs) in a MPTP induced Parkinson’s disease rat model. Background: PD…Levodopa-Induced Dyskinesias in Patients with Parkinson’s Disease in the Uzbek Population
Objective: To investigate the clinical features and prevalence of levodopa-induced dyskinesias in patients with Parkinson’s disease in the Uzbek population. Background: Levodopa-induced dyskinesias (LID) are…From Vision to Reality: Nursing Driven Implementation, Policy, and Safety Framework for Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion in a Tertiary Movement Disorder Centre
Objective: To describe the development of nursing roles, policies, and safety processes supporting implementation of foslevodopa/foscarbidopa infusion therapy for advanced Parkinson’s disease in a tertiary…Muscarinic receptor antagonism beyond M4 is required for efficacy in a preclinical model of dystonia and Parkinson’s disease
Objective: To inform the target activity profile of future movement disorder therapies, pre-clinical studies quantified the contribution of M4 receptor occupancy (M4RO) to reversal of…Normative Data for the IDEA Dementia Screen in Healthy Older Adults and People with Parkinson’s Disease in Ethiopia: A Comparative Cross Sectional Study
Objective: This study aims to establish Ethiopian normative data for IDEA in healthy older adults and People with Parkinson's disease, and to evaluate its appropriateness…Wearable assessment of levodopa-entacapone-carbidopa intestinal gel treatment characteristics at home: Pilot Protocol
Objective: To determine whether symptom profiles of levodopa-entacapone-carbidopa intestinal gel therapy can be effectively captured using continuous smartwatch-based monitoring compared to patient diaries and clinical…QSM-Based Substantia Nigra Volumetry Improves Differentiation of Progressive Supranuclear Palsy from Parkinson’s Disease and Multiple System Atrophy
Objective: To evaluate whether quantitative susceptibility mapping (QSM)-based substantia nigra (SN) volumetry improves differentiation of progressive supranuclear palsy (PSP) from Parkinson’s disease (PD) and multiple…Automated CRST Spiral Drawing Scoring Using a Multimodal Vision-language model: Development and Validation in a Large Essential Tremor Cohort
Objective: The Clinical Rating Scale for Tremor (CRST) is widely adopted for quantifying upper extremity tremor severity in essential tremor (ET), yet manual scoring remains…
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