Continuous Subcutaneous Apomorphine Infusion in Parkinson Disease: Final Data from the Multi-Year InfusON Open-Label Extension Study
Objective: Report outcomes from the multi-year extension to the 52-week open-label InfusON study (NCT02339064)1 of continuous subcutaneous apomorphine infusion (CSAI). Background: The US phase 3…Impaired Retention of Goal-Directed Movements in Parkinson’s Disease: A 2-Year Longitudinal Analysis
Objective: Many uncertainties remain regarding the motor learning challenges faced by individuals with PD, specifically in retaining and recalling acquired motor skills over time without…Sensor-based quantification of dyskinesia in Parkinson’s Disease: supervised vs unsupervised settings
Objective: To investigate whether sensor-derived metrics can quantify dyskinesia in Parkinson’s disease (PD), and to compare supervised and unsupervised assessments. Background: Dyskinesia is a common…Affective Symptom Burden in Individuals with Olfactory Dysfunction in the PREDICT-PD Cohort
Objective: To investigate associations between hyposmia (olfactory dysfunction) and affective symptom burden in PREDICT-PD participants. Background: Anxiety, depression, and hyposmia are common non-motor features of…Identification of a sporadic dystonia-related brain network using resting-state fMRI and machine learning
Objective: To identify and characterize sporadic dystonia-related network (SDRN) using resting-state fMRI (rs-fMRI) and machine learning. Background: Sporadic dystonia is a hyperkinetic movement disorder characterized by…The Unholy Marriage Between Ogilvie Syndrome and Parkinson’s Disease
Objective: To demonstrate the dynamic interplay between advanced Parkinson’s disease (PD)–related colonic dysmotility and acute colonic pseudo-obstruction (ACPO; Ogilvie syndrome) and to highlight practical red…Association of one-year group-based telerehabilitation with quality of life in Parkinson’s disease
Objective: To examine changes in quality of life (QoL) over 1 year in Parkinson’s disease (PD) patients participating in group-based telerehabilitation (TR), and to explore…Deep brain stimulation improves levodopa-induced dyskinesias beyond medication reduction in Parkinson’s disease
Objective: To determine whether the improvement in levodopa-induced dyskinesias after deep brain stimulation is primarily associated with reduction in dopaminergic medication or with a direct…Intranasal spray for nose-to-brain drug delivery: Emergency treatment of OFF episodes in Parkinson’s disease
Objective: To evaluate a novel nose-to-brain nasal spray (XJN010) for emergency treatment of OFF episodes in Parkinson's disease (PD) via clinical pharmacokinetics, safety, and tolerability.…Oral Frailty in Patients with Parkinson’s Disease: A Cross-Sectional Study Using the OF-5 Checklist
Objective: To investigate the prevalence of oral frailty (OF) in patients with Parkinson’s disease (PD) and to explore its clinical examine correlates. Background: The concept…
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