Patient-Derived α-Synuclein Kinetic Subtypes Drive Distinct Pathological Propagation Patterns and Brain Network Alterations in Parkinson’s Disease Mouse Models
Objective: To validate whether patient-derived α-synuclein (α-Syn) aggregates with distinct kinetic properties produce differentiated pathological propagation patterns, brain network functional alterations, and behavioral phenotypes in…Complete and sustained remission of cervical dystonia after repeated dual-target low-frequency rTMS (right M1 + left cerebellum): a 2-year follow-up case report
Objective: To report the clinical course and long-term outcome of repeated 1 Hz rTMS (right M1 + left cerebellum) in a botulinum toxin-naïve idiopathic cervical…The Role of Electrophysiology in Preventing Diagnostic Misclassification of a Craniocervical Dystonia
Objective: To illustrate the utility of EMG/NCS in diagnosing a paroxysmal craniocervical dystonia confounded by features mimicking seizure and functional movement disorder (FMD). Background: A…Factors Associated with Efficacy and Safety of Unilateral Thalamic MRgFUS in Essential Tremor: A Single-Center Cohort Study
Objective: To identify factors associated with treatment efficacy and safety of unilateral thalamic magnetic resonance-guided focused ultrasound (MRgFUS) in patients with essential tremor (ET). Background:…APOSTIM study: a prospective study on quality of life in Parkinsonian patients sequentially treated with apomorphine infusion and STN stimulation
Objective: The APOSTIM study aimed to compare the quality of life (QoL) in Parkinson’s disease (PD) patients treated sequentially with continuous subcutaneous apomorphine infusion (CSAI)…Voice-Based Screening of Parkinsonian Disorders Using Acoustic Feature Analysis and Machine Learning
Objective: To evaluate whether acoustic features from voice recordings can distinguish Parkinson’s disease and related parkinsonian disorders from healthy controls. Background: Speech production depends on…Omaveloxolone in a real-world setting: implications in Friedreich Ataxia beyond the classic study population
Objective: The aim was to monitor safety and efficacy of omaveloxolone treatment in a single center real life cohort, focusing on Friedreich Ataxia (FRDA) patients…Dual device-aided therapy in advanced Parkinson’s Disease: combining bilateral deep brain stimulation and continuous subcutaneous foslevodopa/foscarbidopa Infusion
Objective: To describe our experience with dual device-aided therapies (DATs). Background: DATs for advanced Parkinson's disease (PD) include deep brain stimulation, continuous subcutaneous apomorphine infusion…Disparate Subregional Striatal DAT-SPECT Associations with CSF-Synucleinopathy Status and Clinical Severity Across Parkinson’s Disease Continuum
Objective: To determine the association between subregional DAT binding ratios (SBRs) for disease risk, PD progression, and whether these associations differ based on SAA status.…Evaluating Gene-Environment Interactions between Head Injury and Parkinson’s Disease Risk Variants.
Objective: To evaluate gene-environment interactions between head injury and candidate single nucleotide polymorphisms (SNP) in Parkinson’s disease (PD). Background: Head injury is consistently associated with…
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