Single-Camera AI Pose Estimation Predicts Clinician-Rated Gait Severity in Cerebellar Ataxia
Objective: We validated a single-camera AI pipeline to predict clinician-rated gait severity in cerebellar ataxia from standard video recordings. Background: Gait instability is among the…Optogenetic mediated inhibition of the subthalamic nucleus alleviates motor symptoms in experimental hemi-parkinsonism mouse model
Objective: Study the potential of optogenetic suppression of STN neurons in alleviating motor symptoms in a PD mouse model using the novel inhibitory opsin eOPN3.…Strategies for Harmonising Clinical Data for Multi-Centre, Large Scale Genome-Wide Association Studies
Objective: To establish a data harmonisation framework for classifying cognitive status in Parkinson’s disease (PD) across multiple study and data types to facilitate large-scale genetic…Rare Neurotoxicity of Cotrimoxazole A Movement Disorder Presentation In Elderly Patient
Objective: We report the case of an elderly woman with hyperkinetic movement disorders Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used for Pneumocystis jirovecii prophylaxis, but significant neurological toxicity…Dietary and Environmental Risk Factors of Parkinson’s Disease: An Integrated Network Pharmacology Approach
Objective: To investigate dietary and environmental determinants of Parkinson’s disease (PD) and related mortality by integrating large-scale clinical phenotyping with network pharmacology and molecular docking…Does Fgatir Hypointensity Predict Outcomes After Deep Brain Stimulation For Action Tremors
Objective: To test whether efficacy of Deep Brain Stimulation (DBS) in different action tremor syndromes (Essential tremor, ET, ET-plus, or dystonic tremor as per IPMDS…Early integrated Dysphagia and Nutritional Management in Parkinsonism: a prospective Feasibility Study to prevent Malnutrition and Complications
Objective: To assess feasibility, safety, adherence, and acceptability of an early integrated dysphagia–nutrition pathway for parkinsonism. Background: Dysphagia in parkinsonism may occur early and remain…Assessment of GCA repeat expansion in the GLS gene among Indian patients with Spinocerebellar Ataxia
Objective: Spinocerebellar ataxia (SCA) is a group of neurodegenerative disorders. More than 40 microsatellite repeat loci have been associated with ataxia. The GCA repeat expansion…Exploratory Results From a Phase 1 Study of NIO752 in Progressive Supranuclear Palsy Supporting Further Clinical Studies
Objective: To report exploratory analyses of biomarker and clinical outcomes from a first-in-human study of NIO752 in progressive supranuclear palsy (PSP) and provide rationale for…When Motion Ceases Twice: Delayed Post-Hypoxic Leukoencephalopathy with Parkinsonism, a Case Report.
Objective: To describe a challenging clinical case of akinetic-rigid syndrome in the setting of delayed post-hypoxic leukoencephalopathy (DPHL). Background: The susceptibility of basal ganglia to hypoxic-ischemic injury can lead to immediate…
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