Three-Year Results from the Largest Prospective Cohort of Directional Subthalamic Deep Brain Stimulation in Parkinson’s Disease to Date
Objective: To evaluate long-term real-world motor, quality-of-life, medication, and safety outcomes in patients with Parkinson’s disease (PD) treated with a multiple-independent-current-control (MICC) directional deep brain…High Step Marching Dyskinesia: A Case Series
Objective: To describe high step marching dyskinesia in two patients with Parkinson's disease (PD) Background: Levodopa-induced dyskinesias can interfere with gait in patients with Parkinson’s…Methamphetamine: An Underrecognized Cause of Acute Chorea – A Case Report and Literature Review
Objective: To report a case of methamphetamine-induced choreoathetosis and review the literature regarding its clinical features, related phenomenology, and treatment response. Background: Acute onset of…Holistic Sensor-Based Profiling of Parkinson’s Disease via Mixed Reality: Implementation and Multimodal Feasibility
Objective: To validate a novel multimodal mixed-reality (MR) platform utilizing HoloLens 2 for the automated assessment of Parkinson’s disease (PD) symptoms and to determine the…Parkinsonism in B-Cell Maturation Antigen-Targeting CAR-T Cell Cancer Therapies
Objective: Describe parkinsonism after B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy for treatment of multiple myeloma. Background: BCMA-targeted CART-cell therapy effectively treats…Phenotypic Evolution from Nonfluent PPA to PSP
Objective: Progressive Supranuclear Palsy (PSP) and Nonfluent Primary Progressive Aphasia (nfvPPA) are clinicopathological entities within the 4-repeat tauopathy (4R tauopathy) spectrum. Increasing evidence suggests that…Wearable-Derived Cardiac Features and Cardiac–Motor Interconnection Across Parkinson’s Disease Severities
Objective: To examine how wearable-derived cardiac performance and cardiac–motor interconnection (CCM) vary across Parkinson’s disease (PD) severities, stratified by the Parkinson’s disease–cognitive rating scale (PD-CRS)…A Deep Learning Model-based Screening System for Nystagmus in Central Vertigo
Objective: We aimed to classify nystagmus videos into central and peripheral nystagmus using a deep learning model. Background: Diverse causes underlie vertigo, and while clinically…Longitudinal Weight/BMI Trajectories and Their Clinical Impact on Parkinson’s Disease.
Objective: To evaluate longitudinal weight/BMI trajectory classes in PwP and their association with motor progression and quality of life (QoL). Background: Weight homeostasis is frequently…Baseline plasma neurofilament light and phosphorylated tau 181 levels predict longitudinal cognitive decline in APOE4 and long SNCA Rep1 carriers in Parkinson’s disease
Objective: Plasma neurofilament light (NfL; a marker of axonal injury) and phosphorylated tau 181 (pTau181) are biomarkers that have been associated with cognitive decline in…
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