Identification of Alpha-synuclein Pathology in Dementia with Lewy Body Participants by Seed Amplification Assay
Objective: To assess frequency and type of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) from dementia with Lewy bodies (DLB) participants by means of…Reducing Cost and Operative Time in DBS with a Consolidated Workflow: A Time-Driven Activity-Based Costing Analysis
Objective: To show that a consolidated patient specific workflow significantly improved operative efficiency and reduced personnel costs for deep brain stimulation (DBS) implantation, without compromise…Longitudinal motor network responses to pallidal DBS in cervical dystonia: an ongoing DBS-fMRI study
Objective: This longitudinal MRI study in cervical dystonia uses functional MRI (fMRI) to evaluate neural mechanisms underlying clinical response to deep brain stimulation (DBS), with…Social Determinants of Health and MSA survival
Objective: To investigate how social determinants of health affect survival in people with Multiple System Atrophy Background: The wider determinants of health (e.g. socioeconomic and…The Lewy Body Dementia Domain Rating Scale (LBD-DRS): Patient and Care Partner Perspectives
Objective: To develop and validate the Lewy Body Dementia Domain Rating Scale (LBD-DRS), a disease-specific outcome measure designed to comprehensively capture the clinical features and…MT200605 for Huntington’s Disease: Nonclinical finding and Phase I Clinical Result
Objective: To summarize the efficacy of the oral MT200605 formulation in a Huntington’s disease (HD) mouse model and current clinical progress of MT200605. Background: MT200605…Plasma Fibrinogen Associates with Dopaminergic Neurodegeneration Independent of Peripheral Inflammation in drug-naïve Parkinson’s Disease
Objective: To investigate the association between plasma fibrinogen (Fib) levels, clinical features, and nigrostriatal dopaminergic neurodegeneration in drug-naïve patients with Parkinson’s disease (PD). Background: Fib…A Novel SPG11 Splice-Site Mutation in Hereditary Spastic Paraplegia: Clinical, Radiologic, and Genetic Insights from the First Philippine Case
Objective: To report the first genetically confirmed case of SPG11-associated hereditary spastic paraplegia (HSP) in the Philippines, featuring a previously undocumented splice-site mutation and comprehensive…Morvan Syndrome Associated with Malignant Thymoma and Double-Positive CASPR2/LGI1 Antibodies
Objective: To report a 38-year-old woman with malignant thymoma who developed Morvan syndrome with double-positive CASPR2 and LGI1 antibodies, presenting with typical features as well…Age-Dependent Peripheral Dissemination of α-Synuclein Seeds: Mechanistic Basis for Blood-Based Early Detection of Parkinson’s Disease
Objective: To evaluate the diagnostic utility of serum α-synuclein (α-Syn) seed amplification assay (SAA) for early PD detection using preformed fibril (PFF)-induced mouse models and…
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