Modeling disease progression in spinocerebellar ataxias
Objective: In the context of emerging gene-targeted therapies for polyglutamine spinocerebellar ataxias (SCAs), identifying predictive clinical markers of disease progression is becoming increasingly relevant. We…Genetic modifiers of the clinical phenotype in Spinocerebellar Ataxia type 2. 25 years of candidate genes studies and the forthcoming GWAS era
Objective: To provide a critical review the state of the art on the search for modifier genes for disease severity of SCA2. Background: Spinocerebellar ataxia…Temporal Ordering of Biomarker Abnormality Events Leading to Cognitive Impairment in Parkinson’s Disease: A Disease Event-Based Model Analysis of the PPMI Cohort
Objective: To estimate the temporal ordering of multimodal biomarker abnormality events leading to cognitive impairment in PD using a Disease Event-Based Model (DEBM), incorporating clinical,…The Impact of Insomnia and Sleep Fragmentation on Quality of Life and Neuropsychiatric Outcomes in Restless Legs Syndrome
Objective: To quantify the prevalence of insomnia, sleep architecture disruption, and their cascading impacts on emotional well-being and overall quality of life in patients with…Clinical Characteristics and Functional Impact of Tremor in Patients with Multiple Sclerosis in Nepal: A Cross-Sectional Observational Study
Objective: To describe the clinical characteristics of tremor in multiple sclerosis (MS) patients in Nepal and assess its functional impact on daily living. To describe…Diet Quality and Nutrient Intake in Parkinson’s Disease: A Multicenter Study in Egypt
Objective: To compare diet quality and nutrient intake between PD patients and controls and examine associations with PD clinical features. Background: Parkinson’s disease (PD) is…The GLP-1 Agonist Paradox in Parkinson’s Disease: A Comparative Analysis of Lixisenatide and Exenatide Phase III Trial Outcomes and Neuroprotective Mechanisms
Objective: To assess the pharmacological and methodological factors underlying the "GLP-1 paradox" by comparing the outcomes of lixisenatide and exenatide, with an emphasis on kinetics,…Effect of clonazepam on restless legs syndrome in a multiparous pregnant woman
Objective: To report a case of a multiparous pregnant woman with severe restless legs syndrome (RLS) in her seventh pregnancy who was treated with a…Sex Differences for Primary Psychiatric Diagnoses and Associated Care Outcomes in Dementia with Lewy Bodies using Epic Cosmos
Objective: Assess sex differences for documented primary psychiatric diagnoses in people with dementia with Lewy bodies (DLB) and their associations with care outcomes (hospitalization, specialty…Modulation of Excitatory/Inhibitory Neurotransmission via Targeting GABAA-Gephyrin Signaling: Integrated In-Silico, In-Vitro, and In-Vivo Evidence in Parkinson’s Disease Models
Objective: To evaluate the neuroprotective potential of wogonin in modulating excitatory–inhibitory neurotransmission via GABAA receptor and gephyrin signaling in rat models of Parkinson’s disease (PD).…
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