Choreoathetosis revealing vitamin B12 deficiency : an unusual manifestation of subacute combined degeneration
Objective: To describe an uncommon case of choreoathetosis secondary to vitamin B12 deficiency, highlighting the importance of recognizing atypical movement disorders linked to metabolic causes.…Outcomes of a new electromyography-guided botulinum toxin injection clinic for medication-refractory upper limb tremor
Objective: To describe the outcomes of a new electromyography (EMG)-guided botulinum toxin (BT) clinic for treatment of tremor in our center. Background: Tremor is often…The Care Assessment Need Score Underestimates 90-Day Mortality in Veterans with Parkinson’s Disease
Objective: To evaluate the Care Assessment Need (CAN) score as an accurate mortality prediction tool in Parkinson's Disease (PD) to facilitate timely end-of-life care needs…Perceived Consequences and Catastrophising Help Explain Health-Related Quality of Life in Parkinson’s Disease
Objective: To examine if illness representations and cognitive-behavioural responses to symptoms explain additional variance in health-related quality of life (HRQoL) beyond demographic and established clinical…Sex Related Differences in Parkinsons Disease Motor and Non Motor Features Treatment Response and Quality of Life
Objective: To assess sex-related differences in motor and non-motor symptoms at diagnosis, disease evolution, treatment response, and quality-of-life impact in patients with Parkinson’s disease. Background:…Cholinergic Basal Forebrain Atrophy Associates with Short-Latency Afferent Inhibition and Cognitive Impairment in Parkinson’s Disease
Objective: To investigate whether cholinergic basal forebrain (cBF) atrophy mediates the relationship between short-latency afferent inhibition (SAI) and cognitive performance in PD. Background: Cognitive impairment…Perceptions and knowledge about Parkinson’s disease fluctuations among patients and caregivers: insights from a qualitative focus group
Objective: To explore the knowledge, perceptions and experiences of people with Parkinson’s disease and caregivers regarding motor and non-motor fluctuations, identifying informational gaps and training…Dopamine Receptor Blocking Drug Exposure is Associated with Parkinson’s Disease
Objective: To test the hypothesis that dopamine receptor blocking agents (DRBAs) contribute to the later diagnosis of Parkinson’s disease (PD). Background: Recent evidence suggests that…Mass balance and metabolism of BIA 28-6156, an allosteric activator of beta-glucocerebrosidase, in humans
Objective: To determine the ADME profile an open-label, single-dose, single period study was conducted with six healthy male subjects. Background: BIA 28-6156 is an allosteric…α-Synuclein biomarkers in prodromal synucleinopathies: a systematic review and meta-analysis.
Objective: To quantify the diagnostic accuracy and predictive performance of α-synuclein biomarkers in isolated REM sleep behaviour disorder (iRBD), pure autonomic failure (PAF), and idiopathic…
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