Senile Plaques and Neurofibrillary Tangles Modulate Lewy Body Distribution: Autopsy Study of 2,308 Cases
Objective: To understand how Lewy body (LB) pathology progresses in the cerebrum and how Alzheimer's disease (AD) pathology influences LB distribution in LB disease (LBD).…Cross-Continental Differences in Prodromal Symptoms of Lewy Body Dementia: A Comparative Analysis Across Asia, Europe, and North America
Objective: To systematically analyze the prevalence of prodromal symptoms in Lewy Body Dementia (LBD) across different continents, focusing on REM sleep behavior disorder (RBD), hallucinations,…Altered Degree Centrality and Its Association with Neurotransmitter Systems in Parkinson’s Disease Patients with Impulse Control Disorders: A Resting-State fMRI Study
Objective: To characterize alterations in local brain function measured by degree centrality (DC) and to explore potential neurotransmitter information in PD patients with ICD (PD-ICD),…Mild Parkinsonian Signs in Prodromal Parkinson’s Disease
Objective: To investigate the prevalence and severity of mild Parkinsonian motor signs in a longitudinal cohort stratified by the Movement Disorder Society (MDS) prodromal risk…Can Parkinson’s Disease and Progressive Supranuclear Palsy be Distinguished Using Surgical Planning Image Analysis Software?
Objective: During deep brain stimulation (DBS), the surgical planning software Elements can automatically identify deep brain structures and calculate their volumes. This procedure is straightforward…Translational Target Engagement of HER-096 Demonstrates Concordant Proteostasis and Mitochondrial Modulation in Preclinical Models and Patients with Parkinson’s Disease
Objective: To evaluate translational target engagement of HER-096, a CDNF-derived peptidomimetic, in preclinical models of Parkinson’s disease (PD) and in a Phase 1b clinical study…DTI-ALPS Insights into Glymphatic Dynamics and Neurovascular Changes in Parkinson’s Disease
Objective: To investigate glymphatic activity, structural small vessel disease (SVD) markers, and white matter microstructure in Parkinson’s disease (PD) patients, and to explore their associations…Distinct FDG-PET metabolic patterns and connectivity alterations in dopamine transporter-deficient versus -preserved MSA-C
Objective: In this study, we stratified MSA-C patients by DaT-PET binding status (preserved vs deficient) and compared their 18F-FDG PET metabolic patterns and inter-regional metabolic…NLRP3 Inhibition in Early-Stage Parkinson’s disease: Results of a Phase Ib Study
Objective: To evaluate the effect of selnoflast, an NLRP3 inhibitor, in persons with early-stage Parkinson’s disease (PD). Background: Damage-associated molecular patterns and pathological alpha-synuclein from damaged or…Metabolic Brain Pattern and Longitudinal Progression in GBA-Associated Parkinson’s Disease Revealed by 18F-FDG PET/CT
Objective: To characterize the cerebral metabolic pattern of GBA-associated Parkinson’s disease (GBA-PD) using 18F-FDG PET/CT and to compare its longitudinal characteristic with genetically undefined Parkinson’s…
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