Digital acoustic assessment of alleviating maneuvers in laryngeal dystonia: a 2-patient case series
Objective: To assess whether digital acoustic analysis can objectively capture posture-dependent symptom modulation in laryngeal dystonia. Background: Objective tools for quantifying alleviating maneuvers in laryngeal…Standardised Home-Based Walk Tests Can Capture Gait Differences in Parkinson’s Disease Using Wearable Sensors
Objective: To evaluate the feasibility and discriminative utility of a standardised home-based walk test using wearable sensors in people with Parkinson's disease (PwP). Background: Wearable…Handwriting in PRKN-PD: A Study of Movement Control
Objective: To explore differences in movement control between PRKN-PD and gene-negative YOPD patients using a structured handwriting task. Background: Idiopathic Parkinson’s disease (IPD) symptoms are…Development and initial feasibility of a Randomised Pilot Trial of Enhanced Tai Chi for Parkinson’s Disease
Objective: To describe the design and feasibility of a randomised controlled pilot study evaluating an Enhanced Tai Chi intervention for people with Parkinson’s disease (NCT07297368).…Biomarker-Informed Survival Modelling Using Plasma Neurofilament Light and Clinical Predictors in a Prospective Multiple System Atrophy Cohort
Objective: To develop and evaluate multimodal survival models in MSA integrating clinical features with plasma NfL. Background: Progression in Multiple System Atrophy (MSA) is highly heterogeneous. Robust…Anticipatory Language Prediction ERPs Detect Early Neurophysiological Changes in Asymptomatic Huntington’s Disease
Objective: To determine whether ERP markers of anticipatory semantic prediction and post-target integration detect early functional brain changes in asymptomatic Huntingtin gene-expansion carriers (HGEC) compared…Proteome-Wide Association and Mendelian Randomization Analyses Identify Plasma GUSB as a Potential Biomarker for Multiple System Atrophy
Objective: To identify plasma protein biomarkers associated with MSA and investigate their potential causal relationships using integrative proteomic and genetic approaches. Background: Multiple System Atrophy…Quanti-tau-PET Study of PI‑2620 Tau-PET Quantification in Progressive Supranuclear Palsy
Objective: *Establish a quantitative analysis framework for PI‑2620 tau-PET in progressive supranuclear palsy (PSP);*Compare tau-PET uptake in PSP versus control subjects;*Assess correlations with clinical variables…Hemoglobin Levels and Non Motor Symptoms in Parkinsons Disease Patients with Modified Hoehn and Yahr Scores
Objective: This study aims to explore the association between hemoglobin (Hb) levels and the severity of non motor symptoms in Parkinson’s disease as evaluated through…Painful legs moving toes spectrum disorders – a systematic review
Objective: To investigate the clinical characteristics of painful legs moving toes (PLMT) spectrum disorders. Background: Classic PLMT is a rare movement disorder characterized by continuous involuntary…
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