International validation of the Neuropsychiatric Fluctuations Scale in patients with Parkinson’s disease
Objective: To evaluate the psychometric properties of the Neuropsychiatric Fluctuations Scale (NFS) in patients with Parkinson’s disease (PD) using classical test theory (CTT) and item-response…Coupling of Cholinergic and Dopaminergic Terminal Loss in Progressive Supranuclear Palsy: A Multimodal [18F]FEOBV and [11C]PE2I Study
Objective: To describe the relationships between dopaminergic and cholinergic terminal deficits in Progressive Supranuclear Palsy (PSP) relative to age-matched Normal controls (NC). Background: There is…Influence of disease stage upon real-world turning performance in people with Parkinson’s
Objective: To explore the influence of disease stage on real-world turning in people with Parkinson’s disease (PD). Background: Turning can be challenging in PD due…Clinical Significance of Imaging Markers for Cerebellar Ataxia and Parkinsonism in Multiple System Atrophy
Objective: To clarify the interactions among clinical features and imaging markers, and to identify factors contributing to disease severity in MSA. Background: Multiple system atrophy…Switch from LCIG to LECIG in advanced Parkinson’s Disease: Real World Outcomes from a Single Centre
Objective: To evaluate the clinical outcomes and tolerability of switching from levodopa/carbidopa intestinal gel (LCIG) to levodopa/carbidopa/entacapone intestinal gel (LECIG) in patients with advanced Parkinson’s…Microglial Inflammatory Signaling Mediates Neuroimmune Dysregulation And Behavioral Dysfunction in A Parkinson’s Disease Model
Objective: To determine whether M1 microglial signaling via FAM19A3, CHI3L1, and VILIP-1 contributes to neuroinflammation, neuronal degeneration, and behavioral dysfunction in a Parkinson’s disease, and…Phasic Hemidystonia Secondary to Cavernoma: A Case of Sustained Response to Botulinum Toxin
Objective: To report a rare case of lentiform nucleus cavernoma with phasic-predominant hemidystonia and sustained BoNT response. Background: Cerebral cavernomas rarely present with movement disorders.…Remote Digital Deployment of a Validated Psychosis Screener in Parkinson’s Disease: Real-World Feasibility and Screening Yield
Objective: To evaluate rapid remote deployment of the Self-Administered Screening Questionnaire for Parkinson's Disease-Associated Psychosis (SASPAP) and assess whether screening identifies unmet need for clinician…Digital Gait Biomarkers Reveal a Distinct Motor Prodrome Up to Five Years Before Parkinson’s Disease Diagnosis in the General Population
Objective: To assess whether novel digital gait biomarkers can predict incident Parkinson’s disease (PD) in a large cohort of middle-aged and older adults; and (ii)…Simultaneous EEG and Pallidal Local Field Potential Recording in the Diagnosis of Paroxysmal Movements in a Patient with PDE2A Mutation
Objective: To describe the diagnostic value of pallidal local field potentials in distinguishing movement disorder from seizure in a complex phenotype. Background: Sensing-capable deep brain…
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