Clinical Profile and Progression of Parkinson’s Disease in Nigerians with the GBA1 African Ancestry-specific Risk Variant
Objective: This study compares clinical features and disease progression across rs3115534 genotypes (G/G, G/T, T/T) in Nigerians with Parkinson's disease (PD). Background: Variants in GBA1 are major…Trancranial Sonography Reveals Striatal Neurodegeneration in the Prodromal Phase of X-linked Dystonia-Parkinsonism
Objective: To use transcranial sonography (TCS) to detect striatal and substantia nigra abnormalities in patients with X-linked dystonia-parkinsonism syndrome (XDP), non-manifesting carriers (NMC) of the…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…Dysregulation of the Intestinal Macrophage CXCL8/CXCR2 Axis and Its Role in α-Synuclein Clearance
Objective: To investigate the role of the CXCL8/CXCL2–CXCR2 axis in intestinal macrophage-mediated clearance of α-syn in PD. Background: PD is characterized by the misfolding, aggregation,…Perplexing Presentation of Myasthenia Gravis in an Elderly Patient with Essential Tremor and Parkinson’s Disease Complex Case Report
Objective: To highlight a complex clinical case of coexisting movement and neuromuscular junction (NMJ) disorders. Background: Essential tremor (ET) is the most common movement disorder…Does Knowing More Mean Tolerating More? Satisfaction with Medication Information and Levodopa Dosage in Parkinson’s Disease
Objective: To characterize the correlation between satisfaction with medication-related information and daily levodopa dosage in Parkinson’s disease (PD) patients presenting with levodopa-related complaints. Background: Adequate…Towards the detection of troublesome dyskinesia in Parkinson’s disease using wearable sensors
Objective: To assess the feasibility of using movement energy heatmaps to detect troublesome dyskinesia in Parkinson’s disease (PD) during activities of daily living. Background: Recently,…Polypharmacy and its Impact in Individuals with Parkinson’s Disease: Theory- and Data-Driven Approaches
Objective: The aim is to explore the relationship between high prescription drug use (polypharmacy), and its unintended effects on individuals with Parkinson’s Disease (PD). Background:…Differences in Lewy body dementia in people from ethnic minorities: a systematic review of epidemiology, diagnosis, clinical features and imaging
Objective: To systematically review evidence on epidemiological and clinical differences in Lewy body dementia (LBD), including dementia with Lewy bodies (DLB) and Parkinson’s disease dementia…Preserved Neuroplasticity in Patients Affected by Parkinson’s Disease Responders to External Auditory Cueing Strategies
Objective: This study aimed to explore whether PD patients responsive to rhythmic auditory cues (RAC), identified by lower gait variability during cued relative to uncued…
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