Glymphatic dysfunction in patients with Parkinson’s disease is associated with regional amygdala and putamen degeneration
Objective: To study the association between multimodal non-invasive MRI glymphatic system proxies and global and deep gray matter (GM) degeneration in patients with Parkinson’s disease (PD). Background: Glymphatic dysfunction has been hypothesized to impair pathological…Effects of LSVT BIG on Balance Dysfunction in Parkinson’s Disease and Its Underlying Cortical Regulatory Mechanisms Using fNIRS
Objective: To systematically investigate the efficacy of an 8-week LSVT-BIG intervention on balance control in patients with Parkinson’s disease (PD), and to explore its potential…Establishing the Diagnosis of Wilson’s Disease using the Leipzig Criteria in Patients with Neurological Manifestation: A Single-Center Observation
Objective: This study assesses the diagnostic efficacy of Leipzig’s (LZ) criteria in establishing the diagnosis of neurological type Wilson’s disease. Background: Wilson's Disease is a…Machine Learning for Early Detection of Huntington’s Disease: Integrating Non-Motor Symptoms and Gender-Specific Differences
Objective: To develop a machine learning (ML) model for early Huntington’s disease (HD) detection by integrating non-motor symptoms (NMS) and DNA methylation patterns, leveraging gender-specific…Myoclonus-Dystonia as a Phenotype of HGPPS1: A Case Report
Objective: To describe a clinical case and the results of genetic analysis in a patient with a combination of HGPPS1 and myoclonus-dystonia. Background: Horizontal gaze…Proposed cognitive indices for the Parkinson’s Progression Markers Initiative
Objective: To propose cognitive indices for the PPMI cognitive battery (PPMI-CB). Background: Cognitive batteries provide meaningful information about Parkinson-related cognitive impairment but are complicated when…Bilateral GPi Deep Brain Stimulation for Severe Speech-Induced Dystonic Dysfluency: A Novel Phenotype at the Stuttering-Dystonia Interface
Objective: To report the first case of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) producing transformative improvement in severe speech-induced dystonic dysfluency at…Identification of Alpha-synuclein Pathology in Primary Tauopathies by Seed Amplification Assay
Objective: To assess intravitam frequency and type of misfolded α-synuclein aggregates (syn-seeds) in participants with clinically defined primary tauopathies, such as progressive supranuclear palsy (PSP)…Adaptive Deep Brain Stimulation Guided by Electrophysiological Mapping for Stimulation-Induced Gluteal Dystonia in Parkinson’s Disease
Objective: To describe the use of electrophysiologically guided adaptive deep brain stimulation (aDBS) and directional volume of tissue activation (VTA) shaping to manage stimulation-induced focal…Face Pareidolia in the East London Parkinson’s Disease Project
Objective: To determine the prevalence of pareidolic illusions in participants enrolled in the East London Parkinson’s Disease (ELPD) Project using the Noise Pareidolia Task (NPT),…
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