Early integrated Dysphagia and Nutritional Management in Parkinsonism: a prospective Feasibility Study to prevent Malnutrition and Complications
Objective: To assess feasibility, safety, adherence, and acceptability of an early integrated dysphagia–nutrition pathway for parkinsonism. Background: Dysphagia in parkinsonism may occur early and remain…Assessment of GCA repeat expansion in the GLS gene among Indian patients with Spinocerebellar Ataxia
Objective: Spinocerebellar ataxia (SCA) is a group of neurodegenerative disorders. More than 40 microsatellite repeat loci have been associated with ataxia. The GCA repeat expansion…Exploratory Results From a Phase 1 Study of NIO752 in Progressive Supranuclear Palsy Supporting Further Clinical Studies
Objective: To report exploratory analyses of biomarker and clinical outcomes from a first-in-human study of NIO752 in progressive supranuclear palsy (PSP) and provide rationale for…When Motion Ceases Twice: Delayed Post-Hypoxic Leukoencephalopathy with Parkinsonism, a Case Report.
Objective: To describe a challenging clinical case of akinetic-rigid syndrome in the setting of delayed post-hypoxic leukoencephalopathy (DPHL). Background: The susceptibility of basal ganglia to hypoxic-ischemic injury can lead to immediate…Telemedicine in Parkinson’s Disease Management: Lessons from Resource-Limited Settings Like Nepal
Objective: To evaluate the feasibility, clinical outcomes, and patient satisfaction of telemedicine-based Parkinson’s disease management in Nepal. Background: Parkinson’s disease (PD) is a chronic neurodegenerative…A prospective single-center study investigating the utility of supportive features in the diagnosis of multiple system atrophy with predominant cerebellar ataxia
Objective: The present study aimed to determine the utility of supportive motor and nonmotor features in differentiating multiple system atrophy (MSA) with predomainat cerebellar ataxia…Intestinal Dysbiosis in Parkinson’s Disease: Mechanisms, Clinical Implications, and Therapeutic Perspectives (2015–2025)
Objective: This narrative review aims to consolidate research published from 2015 to 2025 regarding abnormalities in gut microbiota in patients with Parkinson’s disease, emphasizing potential…Efficacy and Safety of Ecopipam for Tourette Syndrome: A Meta analysis of Controlled Trials
Objective: To evaluate the efficacy and safety of ecopipam for tic reduction in Tourette syndrome (TS). Background: Ecopipam, a selective dopamine D1 receptor antagonist, has…Bidirectional Association Between Gout and Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To evaluate whether gout influences the risk of Parkinson’s disease (PD) and whether PD influences the subsequent risk of gout. Background: Gout and PD…Determinants of Quality of Life According to Brain-first and Body-first in Patients with Parkinson’s Disease
Objective: In this study, we aimed to investigate the potential determinants of QoL in brain-first and body-first patients with PD. Background: Parkinson’s disease (PD) is…
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