The GLP-1 Agonist Paradox in Parkinson’s Disease: A Comparative Analysis of Lixisenatide and Exenatide Phase III Trial Outcomes and Neuroprotective Mechanisms
Objective: To assess the pharmacological and methodological factors underlying the "GLP-1 paradox" by comparing the outcomes of lixisenatide and exenatide, with an emphasis on kinetics,…Effect of clonazepam on restless legs syndrome in a multiparous pregnant woman
Objective: To report a case of a multiparous pregnant woman with severe restless legs syndrome (RLS) in her seventh pregnancy who was treated with a…Sex Differences for Primary Psychiatric Diagnoses and Associated Care Outcomes in Dementia with Lewy Bodies using Epic Cosmos
Objective: Assess sex differences for documented primary psychiatric diagnoses in people with dementia with Lewy bodies (DLB) and their associations with care outcomes (hospitalization, specialty…Modulation of Excitatory/Inhibitory Neurotransmission via Targeting GABAA-Gephyrin Signaling: Integrated In-Silico, In-Vitro, and In-Vivo Evidence in Parkinson’s Disease Models
Objective: To evaluate the neuroprotective potential of wogonin in modulating excitatory–inhibitory neurotransmission via GABAA receptor and gephyrin signaling in rat models of Parkinson’s disease (PD).…Risk factors associated with Parkinson’s disease in the DRC (Case of the Initiative Plus Hospital Center, Kinshasa)
Objective: identify factors that could be associated with Parkinson's disease in Congo Background: In DRCongo, few studies have been published on Parkinson's disease to date.At…Long-Term Instability of GPi Gamma Oscillations in Parkinson’s Disease: A Case Study
Objective: To characterize longitudinal changes in globus pallidus internus (GPi) finely tuned gamma (FTG) oscillations during chronic deep brain stimulation (DBS) in a patient with…Clinical Profile and Key Correlates of Genetic Load, Motor Severity, and Caregiver Burden in an Iranian Huntington’s Disease Cohort
Objective: To characterize an Iranian Huntington’s disease (HD) cohort and quantify associations between CAG repeat length, age at onset, motor severity, and caregiver burden. Background:…Effects of Immersive Gamification Technology on the Physical Function of People with Parkinson’s Disease: A Scoping Review
Objective: This scoping review serves to provide an overview of the methods and effects of different ImGTS on various aspects of physical function (e.g., balance,…Telerehabilitation Versus Conventional Therapy in Parkinson’s Disease: Evidence from Randomized Controlled Trials
Objective: To compare the effects of telerehabilitation and conventional rehabilitation on motor function and quality of life (QoL) in patients with Parkinson’s disease (PD). Background:…Clinical and genetic analysis of Kuwaiti and Saudi families exhibiting CLN5 adult-onset autosomal recessive spinocerebellar ataxia. A potential founder mutation
Objective: To characterize the genetic and phenotypic characteristics of patients from five unrelated families with adult-onset ataxia Background: Biallelic variants of the CLN5 gene were…
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