Objective Characteristics and Brain Network Alterations in Early-Stage Parkinson’s Disease with Gastric Motility Disorder
Objective: To characterize objective gastric motility disorder (GMD) in early-stage Parkinson’s disease (PD) and explore the underlying central neural network and structural alterations using multimodal…Pelvic periosteal stimulation for Axial Rigidity in Parkinson’s Disease: A Retrospective Case Series
Objective: To describe clinical changes following pelvic periosteal stimulation in patients with Parkinson’s disease (PD) and axial symptoms. Background: Axial symptoms in PD, including postural…Long-term evolution of deep brain stimulation parameters in Parkinson´s Disease: A 6-year analysis.
Objective: Characterize longitudinal evolution of Deep Brain Stimulation (DBS) parameters in patients with Parkinson´s Disease (PD) over a 6-year period and evaluate stability of programming…Allogeneic iPSC-Derived Dopaminergic Progenitor Transplantation for Parkinson’s Disease: A Phase 1, Dose-Escalation Trial
Objective: To evaluate the safety, tolerability, and preliminary efficacy of putaminal implantation of XS411 (allogeneic iPSC-derived dopaminergic progenitors) in advanced PD (NCT07080775). Background: Parkinson’s disease (PD)…Thalamic Hub Dysregulation in FCMTE1: Multimodal MRI and Gene-Imaging Evidence
Objective: To characterize brain network abnormalities and gene-imaging associations in genetically confirmed FCMTE1 (SAMD12) patients using multimodal MRI. Background: Familial cortical myoclonic tremor with epilepsy…Efficacy of Deutetrabenazine in Patients with Tourette Syndrome: A Meta-Analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy of deutetrabenazine in patients with Tourette syndrome (TS). Background: Deutetrabenazine is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor. While…Wearable Sensors Identify Mobility Features Associated With Parkinson’s Disease Years Before Clinical Diagnosis
Objective: To evaluate longitudinal prospective progression from gait and mobility data from individuals who were later diagnosed with PD. Background: Diagnosis of clinical Parkinson's disease…Low-Intensity Treadmill Training Preserves Motor Function and Muscle Mass Through Mitochondrial and Antioxidant Regulation in a Rat Model of Parkinson’s Disease
Objective: To identify an exercise regimen with the greatest neuroprotective benefit in Parkinson’s disease (PD) and determine whether low-intensity treadmill training preserves motor function and…A Rare Case of PLA2G6 Gene Related Early-Onset Dystonia-Parkinsonism; What Not to Miss Clinically and Radiologically
Objective: PLA2G6-associated neurodegeneration (PLAN) is a rare form of neurodegeneration with brain iron accumulation (NBIA) leading to heterogeneous clinical manifestation including infantile neuroaxonal dystrophy, atypical…Prevalence of drooling in Parkinson’s disease: a multi-center observational study
Objective: This study investigated the prevalence of drooling and related factors. Background: The prevalence of drooling in Parkinson's disease (PD) varies widely, from 10% to…
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