Dopaminergic reconfiguration of an inverted network hierarchy in Parkinson’s disease
Objective: To determine how acute dopaminergic treatment reshapes large-scale brain network organization in Parkinson’s disease (PD). Background: Dopamine replacement reliably improves motor symptoms in PD,…Synchronous Unilateral Pendular Nystagmus and Palatal Myoclonus After Pontine Hemorrhage: A Case Report
Objective: To present a post-stroke pontine bleed patient who developed a rare movement disorder with a treatment approach. Background: A 43-year-old male presented with involuntary…Relationship Between Perceived and Actual Gluteal Muscle Activation in Parkinson’s Disease
Objective: To examine the relationship between the subjective sense of gluteal activation and actual muscle activity during a quadruped hip extension task in individuals with…Investigating the role of ATP7B heterozygous variants in Parkinson’s Disease
Objective: WD often includes parkinsonism and copper dysregulation is implicated in Parkinson’s disease (PD), we investigated whether heterozygous ATP7B variants are associated with increased PD…Seven-Year Outcome of Focused Ultrasound Thalamotomy in Tremor Dominant Parkinson’s Disease Patients
Objective: To assess 7-year outcomes of unilateral MRI-guided focused ultrasound (MRgFUS) ventral intermediate nucleus thalamotomy in tremor-dominant Parkinson’s disease (TDPD) patients with levodopa-unresponsive tremor, and…Subthalamic low-frequency activity reflects engagement during live sports viewing
Objective: To investigate subthalamic nucleus (STN) low-frequency dynamics during emotional engagement while watching live sports in patients with Parkinson's disease treated with adaptive deep brain…Genetic Architecture Of Intracranial Brain Calcification: A Systematic Review
Objective: To systematically identify monogenic disorders associated with intracranial intraparenchymal brain calcification and synthesise their clinical, radiological and molecular features. Background: Brain calcification is a…Allied Health Professionals in Movement Disorders: a survey of clinical practice and education needs across the world
Objective: To understand the breadth and scope of clinical practice and education needs of the Allied Health Professionals (AHP) involved in the care of Patients…Association Between Liver Function and Motor Symptoms in Parkinson’s Disease: A Cross-cohort Analysis of Chinese and PPMI patients
Objective: This study aimed to compare liver function profiles between Chinese PD patients and an international cohort from Parkinson’s Progression Markers Initiative (PPMI), and to…Phase 1 Study of BT-267, a potent, selective, brain-penetrant, and oral small molecule inhibitor of LRRK2
Objective: The aim of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BT-267 in healthy adults. Background: Leucine rich repeat kinase…
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