Resting-state functional network alterations in early Parkinson’s disease anxiety: a 7T MRI study
Objective: To investigate alterations in functional connectivity (FC) within and between key resting-state networks in early Parkinson’s disease patients with anxiety, using 7-Tesla (7T) MRI.…Microsaccade Alterations and Clinical Correlates in Parkinson’s Disease
Objective: To delineate microsaccade dynamics in people with Parkinson’s disease (PD) compared with healthy controls (HC) and to examine their associations with disease-related dysfunction. Background:…Correlating Start Hesitation and Subthalamic Nucleus Activity in Parkinson’s Disease Using Intraoperative Microelectrode Recordings and a Virtual Reality Task
Objective: To investigate the modulations in subthalamic nucleus (STN) signals that are associated with prolonged gait initiation duration in a virtual reality gait task in…PET Imaging of Presynaptic Terminals with [18F]SynVesT-1 in Premanifest Huntington’s Disease
Objective: To assess synapse loss in vivo in late premanifest Huntington’s disease (HD) subjects using [18F]SynVesT-1 positron emission tomography (PET). Background: Synaptic damage is believed…Tremorography as an objective marker of the response after MRgFUS VIM in essential tremor and Parkinson’s disease
Objective: To assess tremorography as an objective tool for evaluating response to MR-guided focused ultrasound (MRgFUS) ventral intermediate nucleus (VIM) thalamotomy in essential tremor (ET) and Parkinson’s…Systemic Inflammation and Cerebral Small Vessel Disease in Progressive Supranuclear Palsy
Objective: To assess the cerebral small vessel disease (CSVD) burden in progressive supranuclear palsy (PSP) and examine the relationships among peripheral inflammatory markers, CSVD imaging…Adaptive Deep Brain Stimulation in Parkinson Disease: Preliminary Single-Center Results
Objective: To describe initial outcomes of alpha-beta (8-30Hz)-guided subthalamic nucleus (STN) adaptive deep brain stimulation (aDBS) in Parkinson disease (PD) in a single-center cohort. Background:…Resting-state pupil fluctuations reflect monoaminergic brainstem dysfunction associated with non-motor symptoms in early Parkinson’s disease
Objective: To determine whether resting-state pupil fluctuations reflect structural and functional impairment of monoaminergic brainstem nuclei and are associated with non-motor symptom burden in early…Clinico-radiological Phenotype of a Unique Family with Mutations in PRKN Over Three Decades
Objective: To report the clinico-radiological phenotype and progression of a female proband and her parents with mutations in the PRKN gene. Background: Bi-allelic PRKN mutations…Suicidal Ideation and Behavior in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects both motor and non-motor neurological functions. In addition to motor impairment, patients frequently experience…
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