Application of the MDS Nonmotor-Symptom Questionnaire in Evaluation of Deep Brain Stimulation Candidates.
Objective: This study explores utility of the MDS Nonmotor-Symptom Questionnaire (MDS-NMS-Q) in neuropsychological evaluations of people with Parkinson’s disease (PwP) considering Deep Brain Stimulation (DBS).…Cortical Dynamics Underlying the Heterogeneous Dopamine Responsiveness of Rest Tremor in Parkinson’s Disease
Objective: To explore neural mechanisms underlying the variable response of rest tremor to dopaminergic treatment by comparing tremor-related cortical oscillations between OFF and ON medication…Postural Stability After CSF Drainage in Idiopathic Normal Pressure Hydrocephalus: Association with Gait Response
Objective: To examine changes in postural stability after CSF drainage using center of pressure (COP) analysis and their association with gait response in patients with…Basal ganglia and cerebellum involvement in Myelin Oligodendrocyte antibody associated disease (MOGAD) presenting with facial Dystonia and limb Tremer
Objective: Movement disorder in MOGAD is rarely reported in literature. Here we report a case of female with facial dystonia and tremor a rare manifestation.…Kufor-Rakeb Syndrome With a Novel Splice-Site Variant in the ATP13A2 Gene
Objective: To report a patient with juvenile-onset parkinsonism harboring a novel homozygous splice-site variant in ATP13A2. Background: Kufor-Rakeb syndrome (KRS) is an ultra-rare form of…Multi-target Deep Brain Stimulation for Dystonia and Complex tremor syndromes: A Single-Centre Case Series and Literature Review
Objective: This clinical study highlights 10 cases treated at the Walton Centre NHS Foundation Trust (Liverpool, UK) wherein DBS has been implemented beyond unilateral and…Nationwide Prevalence of Parkinson’s Disease in Slovakia: A Municipality-Level Analysis
Objective: To determine the nationwide prevalence of Parkinson’s disease (PD) in Slovakia at the level of individual municipalities, with the aim of identifying potential local…All Left: A Case of Ipsilateral Stimulation Induced Dyskinesia
Objective: Stimulation induced dyskinesia is a known phenomenon in subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson’s disease. However, stimulation induced dyskinesia affecting the…Clinical and Biomarker Trajectories in GBA1 Non-Manifesting Carriers With and Without α-Synuclein Seed Amplification Positivity
Objective: To characterize clinical and biomarker features of GBA1-NMC and evaluate whether CSF-αSynSAA status is associated with longitudinal clinical progression and phenoconversion. Background: Pathogenic variants…Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders
Objective: To describe and assess biological congruency, defined as expected biological profile based on abnormal CSF α-synuclein Seed Amplification Assays (CSFaSynSAA) and dopamine transporter SPECT…
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