STN Neuronal Activity Shows Complex and Patient-Dependent Differences in Akinetic-Rigid Parkinson’s Disease With and Without Dystonia
Objective: The aim of the current study is to distinguish and characterize subthalamic (STN) neuronal activity specifically related to dystonia in Parkinson’s disease (PD) patients.…Frontal Cortical Reactivity Underlying Cue Responsiveness in Parkinson’s Disease: a TMS-EEG Study
Objective: To explore the neural mechanisms underlying responsiveness to gait cueing in PD by assessing cortical reactivity using TMS-EEG. Background: External cueing improves gait in…Quantitative Changes in Speech After Focused Ultrasound Subthalamotomy and Thalamotomy in Parkinson’s Disease
Objective: To assess speech outcomes in Parkinson’s disease (PD) patients following unilateral MR-guided focused ultrasound (MRgFUS) targeting the subthalamic nucleus (STN) and ventral intermediate nucleus…Effectiveness of Switching from Levodopa-Carbidopa Intestinal Gel to Levodopa-Carbidopa-Entacapone Intestinal Gel in Patients with Refractory Biphasic and Peak-of-Dose Dyskinesia
Objective: To evaluate the clinical benefit on motor complications of transitioning from levodopa-carbidopa intestinal gel (LCIG) to levodopa-carbidopa-entacapone intestinal gel (LECIG) in a cohort of…Lysosomal polygenic risk score in Parkinson disease across populations.
Objective: (1) Evaluation of lyso-PRS performance for PD status across diverse populations; (2) Comparison of the lyso-PRS across idiopathic PD (iPD), GBA1-PD, non-manifesting GBA1 carriers…Adolescent-onset Myoclonus Dystonia in MT-ND6 m.14487T>C–Associated Leigh Syndrome
Objective: To describe the clinical and genetic features of an adolescent patient with MT-ND6-associated Leigh syndrome presenting with a prominent dystonia and myoclonus. Background: Leigh…Globus Pallidus Internus Deep Brain Stimulation for Dystonia in COX20-Related Mitochondrial Complex IV Deficiency (MC4DN11): First Reported Case
Objective: To describe the clinical response to bilateral GPi-DBS in a patient with MC4DN11-associated dystonia. Background: Mitochondrial Complex IV Deficiency, Nuclear Type 11 (MC4DN11), caused…Acute Hemichorea as a Rare Presentation of Right Temporoparietal Infarction: A Case Report
Objective: This case illustrates acute hemichorea as a rare manifestation of right temporo-parietal infaction. Background: Acquired chorea can result from structural, metabolic, infectious pharmacological, or…Cognitive and neuropsychiatric effects of home-based, remotely supervised strength exercise combined with guideline-based aerobic physical activity modification in Parkinson’s Disease: a randomized controlled trial
Objective: To evaluate the effects of a 24-week home-based, remotely supervised strength exercise program combined with guideline-based aerobic physical activity modification on cognitive function and…An AI-Based Wearable Device Application To Assess Motor Skills Anomalies Associated with Parkinson’s Disease
Objective: The objective of this work was to develop a novel wearable device-based framework for simple at-home motor skills testing paired with a machine learning…
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