Association of Sarcopenia with Fear of Falling and Falls in patients with Parkinson’s disease
Objective: This study aimed to determine whether Sarcopenia is related to the risk of falls and to the Fear of Falling (FOF) in patients with…Sex Differences in the Reported Prodromal Symptoms of Parkinson’s Disease (PD) in the Fox Insight Cohort
Objective: To identify differences in the self-reported prodromal symptoms of male vs female persons with PD (PwPD) in the Fox Insight (FI) cohort. Background: Early…Antidepressants in Huntington’s Disease: A Meta Analysis of Mood and Motor Outcomes with Placebo-controlled Trials
Objective: To evaluate the efficacy of antidepressants for depression in Huntington’s disease (HD). Background: Depression is highly prevalent in HD. Despite frequent clinical use of…Efficacy and Safety of Mesdopetam (IRL790) for Levodopa Induced Dyskinesia in Parkinson’s Disease: A Meta analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy and safety of mesdopetam compared with placebo for levodopa‑induced dyskinesia (LID) in Parkinson’s disease (PD). Background: Mesdopetam (IRL790) is a…Pharmacogenomic Analysis of KM-819-Related Hepatotoxicity in Patients with Multiple System Atrophy
Objective: This study aimed to identify genetic risk factors linked to a drug candidate for MSA (KM-819)-associated drug-induced liver injury (DILI) in patients with multiple…Nigrostriatal Dopaminergic Impairment Patterns in Idiopathic Normal Pressure Hydrocephalus Identified by 18F-FP-DTBZ PET: a 5-Year Longitudinal Study
Objective: To delineate the pattern of nigrostriatal dopaminergic dysfunction in iNPH, explore inter-individual heterogeneity, and evaluate its association with clinical features and long-term outcomes. Background:…Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids
Objective: This study aims to determine how patient-specific microglia influence phospho-α‑synuclein aggregation and contribute to disease-relevant phenotypes within human midbrain organoids. Background: Parkinson’s disease (PD)…An Ongoing Phase 1/2, Multi-center, Open Label Study of NouvNeu001 for the Treatment of Advanced Parkinson’s Disease
Objective: This ongoing, phase 1/2, multi-center, open label study aims to evaluate the safety, tolerability, and efficacy of NouvNeu001 (NCT#06167681) for treating mid to late-stage…Movement decoding from subthalamic nucleus during deep brain stimulation surgery
Objective: To evaluate motor classification and somatotopy of local field potentials (LFPs) recorded from subthalamic nucleus (STN) directional deep brain stimulation (DBS) electrodes. Background: STN…TMEM106B Fibrils Potentiate Pathological α-Synuclein Aggregation in Parkinson’s Disease
Objective: To determine whether transmembrane protein 106B (TMEM106B) fibrils promote α-synuclein (α-syn) aggregation and to elucidate the molecular basis of this interaction in Parkinson’s disease…
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