Structural-Functional Coupling Supporting Motor Reserve in Early-Stage Parkinson’s Disease
Objective: To explore whether motor reserve in early Parkinson's disease (PD) is related to structural-functional coupling (SFC) Background: Motor reserve contributes to individual variability in…Elucidating the demographic distributions and implications of GBA1 gene variants in Parkinson’s Disease.
Objective: Estimating the distribution of GBA1 variants and estimating GBA1 odds ratios for Parkinson’s disease in the UK-based population. Background: Mutations in GBA1 are an…Environmental Risk Factor Co-Exposure as Drivers of Parkinson’s Disease Development: A Scoping Review
Objective: To map and synthesise epidemiological evidence assessing environmental co-exposures and Parkinson’s disease (PD) risk Background: PD is a multifactorial neurodegenerative disorder attributed to genetic,…Neural Network Reorganization Mediates the Analgesic Effects of Repetitive Transcranial Magnetic Stimulation in Parkinson’s Disease
Objective: To evaluate the efficacy of high-frequency M1-rTMS for musculoskeletal pain in PD and investigate its underlying neurophysiological mechanisms using multimodal electrophysiology and imaging. Background:…Clinical Profile and Progression of Parkinson’s Disease in Nigerians with the GBA1 African Ancestry-specific Risk Variant
Objective: This study compares clinical features and disease progression across rs3115534 genotypes (G/G, G/T, T/T) in Nigerians with Parkinson's disease (PD). Background: Variants in GBA1 are major…Trancranial Sonography Reveals Striatal Neurodegeneration in the Prodromal Phase of X-linked Dystonia-Parkinsonism
Objective: To use transcranial sonography (TCS) to detect striatal and substantia nigra abnormalities in patients with X-linked dystonia-parkinsonism syndrome (XDP), non-manifesting carriers (NMC) of the…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…Dysregulation of the Intestinal Macrophage CXCL8/CXCR2 Axis and Its Role in α-Synuclein Clearance
Objective: To investigate the role of the CXCL8/CXCL2–CXCR2 axis in intestinal macrophage-mediated clearance of α-syn in PD. Background: PD is characterized by the misfolding, aggregation,…Perplexing Presentation of Myasthenia Gravis in an Elderly Patient with Essential Tremor and Parkinson’s Disease Complex Case Report
Objective: To highlight a complex clinical case of coexisting movement and neuromuscular junction (NMJ) disorders. Background: Essential tremor (ET) is the most common movement disorder…Does Knowing More Mean Tolerating More? Satisfaction with Medication Information and Levodopa Dosage in Parkinson’s Disease
Objective: To characterize the correlation between satisfaction with medication-related information and daily levodopa dosage in Parkinson’s disease (PD) patients presenting with levodopa-related complaints. Background: Adequate…
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