Does Subthalamic Nucleus DBS Produce Sustained Improvement in Postural Abnormalities? A 5 Year Prospective Study
Objective: To evaluate the long-term effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on postural abnormalities in patients with advanced Parkinson’s disease (PD). Background:…Motor and Non-motor Outcomes of Globus Pallidus internus Deep Brain Stimulation for Dystonia
Objective: This study aims to assess the response to GPi DBS in patients presenting with various types of dystonia and to co-relate the motor as…A Specialized 3D-Printed Device for Gait Rehabilitation in Parkinson’s: Development and Application.
Objective: To develop and evaluate the efficacy of a specialized 3D-printed device designed to correct gait disorders in Parkinson's disease by enhancing step initiation via…Hepatic Biomarker Profile Across Parkinson’s Disease Severity Stages in a Peruvian Cohort
Objective: To determine changes in serum hepatic biomarker concentrations according to Parkinson's disease (PD) severity in Peruvian adults. Background: PD is a progressive neurodegenerative disorder.…Clinical Stage According to Hoehn & Yahr Scale as a Predictor of Non-Motor Symptom Severity in Parkinson’s Disease: A Cross-Sectional in Peru
Objective: To determine the association between clinical stage of Parkinson's disease (PD), according to the Hoehn & Yahr (H&Y) scale, and the severity of non-motor…Blood glucose homeostasis is conserved in patients with mild to moderate Spinocerebellar Ataxia type 2
Objective: To explore novel molecular biomarker candidates for SCA2, based on the assessment of blood glucose homeostasis. Background: Spinocerebellar ataxia type 2 (SCA2) is a…Dual-Task Cost Assessment in Parkinson’s Disease: A Literature Review of Clinical Applications and Measurement Approaches
Objective: This literature review examines current evidence on dual-task cost assessment in PD, focusing on measurement approaches, clinical relevance, and factors influencing performance. Background: Parkinson’s…A Clinical Mapping Framework for Motor Balance Impairment in Welders Projected Against Parkinson Disease Severity Stages
Objective: To determine whether welders exhibit Parkinsonian-like motor balance phenotypes by projecting clinical balance scores into Hoehn and Yahr severity space using a PD-trained predictive…Genotype-Phenotype Correlations in KCNMA1 Channelopathy: A Comparative Analysis of Gain-of-Function and Loss-of-Function Variants in a Korean Cohort and Literature Review
Objective: The objectives of this study are to delineate the distinct genotype-phenotype correlations between gain-of-function and loss-of-function KCNMA1 variants by analyzing a novel clinical cohort…Ulixacaltamide Demonstrates Superiority Over Placebo as Monotherapy and as Add-on to Propranolol in Essential Tremor: Phase 3 ESSENTIAL3 Study 1
Objective: To evaluate efficacy of ulixacaltamide, a selective T-type calcium channel modulator, versus placebo in adults with essential tremor (ET) as monotherapy and as add-on…
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