Neurological Wilson’s disease: another form of tauopathies?
Objective: The authors would hope to identify distribution of Tau protein within the brain of Wilson's disease patients by tau-targeted positron emission tomography (PET) tracers Background:…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Beta and Gamma Local Field Potentials in Chronic Deep Brain Stimulation for Parkinson’s Disease: Programming Implications from a Systematic Review
Objective: To define distinct clinical roles of beta- and gamma-band local field potential (LFP) biomarkers in chronic deep brain stimulation (DBS) for Parkinson’s disease (PD)…Clustered Difference of Gut Microbiome in Helicobacter pylori-negative and positive Group Effect on Clinical Motor Symptoms in PD (Helicobacter pylori-Stool Microbiome or HP-SM Trial)
Objective: This study aims to evaluate the therapeutic effect of H.pylori eradication on clinical motor symptoms in PD and the association between gut microbiomes. Background: Previous…Feasibility and Preliminary Outcomes of an Online Fatigue Self Management Programme for People With Parkinsons Disease
Objective: To assess the feasibility, acceptability, and preliminary outcomes of an online fatigue self management programme for people with Parkinsons disease. Background: Fatigue is a…Developing a toolkit for the assessment and management of lower urinary tract symptoms in parkinsonism
Objective: To develop an easy to use toolkit that expedites the work-up and management of lower urinary tract symptoms (LUTS) in people with parkinsonism for…Integrated and Multidisciplinary Care for Older Adults with Parkinson’s Disease: A value-driven approach
Objective: To evaluate value driven outcomes of an integrated multidisciplinary Parkinson’s clinic for older adults in Singapore Background: Parkinson’s Disease (PD) is a complex neurodegenerative…Nutritional Assessment in X-linked Dystonia Parkinsonism: Preliminary Results from a Pilot Study
Objective: This pilot study aims to evaluate the nutritional status of XDP patients using anthropometric measurements and nutritional assessment tools, and to determine the prevalence…Neurological disease progression in adults with ataxia telangiectasia – a longitudinal study
Objective: To evaluate longitudinal neurological disease progression in the largest available worldwide cohort of adults with ataxia-telangiectasia. Background: Ataxia-telangiectasia (AT) is a rare, multisystem neurodegenerative…
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