Why Context Matters: The Influence of Medication and Environment on Real-World Gait in People with Parkinson’s Disease
Objective: To quantify the extent to which contextual factors explain the variability in real-world gait outcomes in people with Parkinson’s disease (PwP) using machine learning…Relationship Between Psychosocial Factors and Tremor Severity in Essential Tremor
Objective: To examine the relationship between psychosocial factors and tremor severity in patients with essential tremor (ET). Background: Essential tremor is one of the most…Olfactory Function as a Biomarker of Disease Progression in Progressive Supranuclear Palsy
Objective: To investigate whether olfactory function predicts disease progression in progressive supranuclear palsy (PSP). Background: Olfactory function is under-investigated in PSP. Emerging evidence from clinico-neuropathological…The Emerging Landscape of Genotype-Stratified Clinical Trials in Parkinson’s Disease and Atypical Parkinsonian Disorders
Objective: To characterize the landscape of genotype-stratified clinical trials in Parkinson’s disease (PD) and atypical parkinsonian disorders (APD), including therapeutic targets, geographic representation, and trial…Atypical vascular parkinsonism from a midbrain lesion with excellent dopaminergic response
Objective: To present a patient with parkinsonism resulting from an ischemic lesion in the midbrain that exhibited a favorable response to dopaminergic therapy, with anatomical…Neuronal aSynuclein Disease Integrated Staging System (NSD-ISS) Reveals Clinically Meaningful Functional Progression and Quality-of-Life Impact in Parkinson’s Disease
Objective: To evaluate the utility of the Neuronal aSynuclein Disease Integrated Staging System (NSD-ISS) in assessing the meaningfulness of stage progression, and associations with quality…Association between probable RBD and reduced CSF 5-hydroxyindoleacetic acid levels in Parkinson’s disease
Objective: To investigate the association between probable RBD (pRBD) and cerebrospinal fluid (CSF) levels of 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, in patients with Parkinson’s…Effects of Phase-Specific Vibrotactile Cueing on Spatiotemporal Gait Parameters in Parkinson’s Disease
Objective: To evaluate the effects of phase-specific vibrotactile cues applied during swing and stance phases of the gait cycle on spatiotemporal gait parameters in people…Complex FGF14 Repeat Expansion in Early-Onset Parkinson’s Disease
Objective: This study describes a unique case of early-onset Parkinson’s disease (PD) linked to a complex repeat expansion at the FGF14 locus. Background: While the…From Clinical Patterns to Symptom-specific Functional Networks in Dyskinetic Cerebral Palsy
Objective: Investigate clinical motor patterns and evaluate symptom-specific functional motor networks in dyskinetic cerebral palsy. Background: Dyskinetic cerebral palsy (DCP) is a complex movement disorder…
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