Tremorography as an objective marker of the response after MRgFUS VIM in essential tremor and Parkinson’s disease
Objective: To assess tremorography as an objective tool for evaluating response to MR-guided focused ultrasound (MRgFUS) ventral intermediate nucleus (VIM) thalamotomy in essential tremor (ET) and Parkinson’s…Systemic Inflammation and Cerebral Small Vessel Disease in Progressive Supranuclear Palsy
Objective: To assess the cerebral small vessel disease (CSVD) burden in progressive supranuclear palsy (PSP) and examine the relationships among peripheral inflammatory markers, CSVD imaging…Adaptive Deep Brain Stimulation in Parkinson Disease: Preliminary Single-Center Results
Objective: To describe initial outcomes of alpha-beta (8-30Hz)-guided subthalamic nucleus (STN) adaptive deep brain stimulation (aDBS) in Parkinson disease (PD) in a single-center cohort. Background:…Resting-state pupil fluctuations reflect monoaminergic brainstem dysfunction associated with non-motor symptoms in early Parkinson’s disease
Objective: To determine whether resting-state pupil fluctuations reflect structural and functional impairment of monoaminergic brainstem nuclei and are associated with non-motor symptom burden in early…Clinico-radiological Phenotype of a Unique Family with Mutations in PRKN Over Three Decades
Objective: To report the clinico-radiological phenotype and progression of a female proband and her parents with mutations in the PRKN gene. Background: Bi-allelic PRKN mutations…Suicidal Ideation and Behavior in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects both motor and non-motor neurological functions. In addition to motor impairment, patients frequently experience…5-year Longitudinal Changes in Non-motor Symptoms and Their Association With Motor Progression in Parkinson’s Disease
Objective: To examine longitudinal relationships between non-motor symptoms (NMS) and motor progression in Parkinson’s disease (PD), and to determine whether baseline NMS predict motor decline…Physical Activity is Associated with Attenuated Motor and Cognitive Progression in Parkinson’s Disease
Objective: To determine whether physical activity (PA) modifies the rate of motor and cognitive progression in Parkinson’s disease (PD) and to identify specific components of…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Role of ApoE in α-Synuclein Pathology
Objective: To investigate whether apolipoprotein E (ApoE) isoforms directly interact with α-synuclein and determine how these interactions influence aggregation dynamics and cellular uptake. Background: The…
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