Subthalamic Deep Brain Stimulation Produces Consistent Improvements in Sleep Quality and Daytime Sleepiness in Parkinson’s Disease: A Systematic Review and Meta-analysis
Objective: This study aims to determine the effects of subthalamic nucleus deep brain stimulation (STN‑DBS) on sleep quality and daytime sleepiness in Parkinson’s disease (PD).…Emerging Roles for Imaging Techniques in Differentiating Underlying Pathologies in Corticobasal Syndrome
Objective: This review evaluates limitations in differentiating underlying pathologies in Corticobasal syndrome (CBS). We summarize available evidence on clinical features, imaging and fluid biomarkers and…Early dopaminergic treatment patterns and 5-year survival in Parkinson’s disease: a nationwide observational study
Objective: To compare the long-term impact of levodopa monotherapy versus early adjunctive therapy combined with levodopa on mortality in PD. Background: Although dopaminergic therapy improves…Prodromal Parkinson’s Disease in Singapore: Motor and Non-Motor Symptom Patterns
Objective: To determine the differences in motor and non-motor symptoms between subjects categorized as Low, Intermediate, or High Risk for future Parkinson’s Disease (PD). Background:…Treadmill-Based Backward Walking Training as a Rehabilitation Strategy in People with Parkinson’s Disease: A Feasibility Study
Objective: To evaluate the feasibility of treadmill-based backward walking training in people with Parkinson’s disease(PwPD) Background: Parkinson’s disease(PD) is a progressive neurodegenerative disorder characterized by…Exploring the Genetic Architecture of Parkinson’s Disease in North Africa
Objective: To investigate the genetic architecture of PD in North Africa, focusing on Tunisian families, and to identify novel genes and variants using whole-genome approaches.…Real-life accelerometer-based detection of DBS effects on tremor and dyskinesia in Parkinson’s disease, trained with ecological momentary assessments
Objective: To detect real-life tremor and dyskinesia fluctuations, using naturalistic wearable data for prediction, and ecological momentary assessments (EMA) data for model training. Background: Parkinson’s…Sequential Multi-Target tDCS Improves Gait in Parkinson’s Disease: A Randomized Controlled Study Using IMU-Based Gait Analysis
Objective: To investigate the effects of sequential multi-target tDCS on gait performance in patients with PD using objective IMU-based gait analysis. Background: Gait impairment and…Extracellular Neuromelanin Promotes Microglial Reactivity in Parkinson’s Disease
Objective: To investigate the interaction between neuromelanin (NM) and microglia in Parkinsons’s Disease (PD) using human post-mortem midbrain tissue and induced pluripotent stem cell (iPSC)…The OxQUIP At-Home Study: Protocol and Preliminary Findings
Objective: To describe the protocol and preliminary findings of a fully remote, longitudinal at-home study in people with Parkinson’s disease (PwP) and healthy controls (HC),…
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