Baseline Factors Associated with Sublingual Apomorphine Film Maintenance Dose
Objective: To identify baseline demographic and clinical factors associated with the final titrated dose of sublingual apomorphine (SL-APO) in patients with Parkinson’s disease (PD) experiencing…Synergistic Impact of Plasma Neurofilament Light Chain and Neuroimaging Deficits on Cognitive Decline in Prodromal Lewy Body Disease
Objective: To assess the synergy between neuroimaging deficits and plasma biomarkers in predicting longitudinal cognitive and motor progression in individuals at high risk for prodromal…“Unexplained” Chorea Explained by Neuronal Antibodies: A Dutch Cohort Study
Objective: To identify neuronal antibodies in patients with unexplained chorea. Background: In recent years, autoimmune causes of chorea are increasingly recognized and the number of…Risk of Serotonin Syndrome in the Combined Use of Selective Monoamine Oxidase B Inhibitors and Serotonin-acting Antidepressants
Objective: We aim to determine the risk of serotonin syndrome with selective monoamine oxidase B inhibitors (MAO-Bi) use, especially when combined with serotonin-acting antidepressants. Background:…Lu AF28996, a Novel Oral D1-like/D2-like Receptor Agonist, May Improve Motor Complications in People with Parkinson’s Disease: Results from an 18-week open-label, Phase 1b Trial
Objective: Evaluate safety, tolerability, and clinical effects of Lu AF28996 in patients with inadequately controlled advanced Parkinson’s disease (PD) experiencing motor fluctuations, with or without…Bisphenol S: A Potential Environmental Modifier of LRRK2-Associated Parkinson’s disease
Objective: To validate candidate environmental modifiers in the LIPAD exposomics study using additional cell lines, and test a proposed “gene-mitochondria-environment axis” in regulating LRRK2-Parkinson's disease…RESET-DBS: An exploratory study on the safety and efficacy of personalized burst-patterned deep brain stimulation (DBS) in Parkinson’s Disease (PD)
Objective: To assess the safety and efficacy of a personalized burst patterned STN-DBS (bDBS) vs. conventional high-frequency DBS (cDBS). Background: A physiological rationale suggests possible…Patient self-rated Improvements with Opicapone: From randomized trials to Phase IV studies in fluctuating Parkinson’s Disease
Objective: To perform a descriptive comparison of patient-reported perception of improvement with opicapone across phase III and IV studies in patients with fluctuating Parkinson’s disease…Real-World Relationship Between Beta-Band LFP Activity and Motor States in Parkinson’s Disease
Objective: To evaluate the relationship between 10-minute averaged beta-band local field potential (LFP) activity recorded from implanted deep brain stimulation (DBS) systems and motor state…Non-Motor Symptoms in Hemifacial Spasm: A Cross-Sectional Study from a Brazilian Public Tertiary Center
Objective: To determine clinical characteristics of non-motor symptoms in patients with primary hemifacial spasm (HFS) at a tertiary public center in Brazil. Background: HFS is…
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