Investigating the Role of Biallelic EPG5 Variants in Parkinson’s Disease
Objective: Investigate EPG5 role in PD aetiology. Background: Disruption of the lysosome-autophagy pathway is a recurrent feature in Parkinson’s disease (PD). EPG5 bi-allelic loss-of-function variants have been…Non‑Motor Outcomes after STN-FUS for Parkinson’s disease
Objective: To assess changes in non-motor symptoms(NMS) in PD after focused ultrasound subthalamotomy(STN-FUS). Background: NMS impair quality of life in PD.STN-FUS improves motor signs in PD but…Increased Pre-Alpha EEG Functional Connectivity Forecasts Future Cognitive Decline in Parkinson’s Disease
Objective: To evaluate whether resting-state EEG functional connectivity (rsEEG-FC) forecasts cognitive decline three years later in Parkinson’s disease (PD). Background: Cognitive performance and trajectories of…Multimodal Gait Analysis Using Video Pose Estimation Deep Learning and Walkway Parameters: Parkinsonism Detection and Phenotyping
Objective: To develop a multimodal framework fusing frontal-view video pose estimation frame coordinates with pressure-sensitive walkway features for parkinsonism detection, and to discover clinically meaningful…Late Diagnosed Kufor Rakeb Syndrome Presenting as Drug Induced Parkinsonism
Objective: Kufor-Rakeb syndrome (KRS) may present with a wide variety of psychiatric symptoms. This case describes the development of parkinsonism after antipsychotic treatment and the…Challenging Traditional Paradigm: Clinical Outcomes of Early vs Late Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Objective: Deep brain stimulation(DBS) of subthalamic nucleus(STN) is an established treatment for Parkinson’s disease(PD). DBS has been reserved for patients with long-standing disease and disabling…Correlation Analysis of Cortical Activation and Aspiration Risk During Swallowing in Patients with Multiple System Atrophy
Objective: To explore whether cortical hemodynamic responses during swallowing are associated with aspiration risk in patients with Multiple System Atrophy for convenient screening method. Background:…Immigration status and Parkinson’s disease: a retrospective matched cohort study
Objective: To investigate whether immigrant status in Parkinson's disease (PD) may be associated with differences in clinical presentation, disease severity, and healthcare engagement. Background: PD…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…Pharmacoscintigraphic Evaluation and Safety of a Novel, Dual-pulse, Delayed-release carbidopa/levodopa Tablet for Bedtime Dosing
Objective: To characterize the pharmacokinetics (PK) of carbidopa (CD) and levodopa (LD) from delayed-release (DR) tablets intended for bedtime administration and to correlate systemic exposure…
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