Ulixacaltamide Demonstrates Superiority Over Placebo as Monotherapy and as Add-on to Propranolol in Essential Tremor: Phase 3 ESSENTIAL3 Study 1
Objective: To evaluate efficacy of ulixacaltamide, a selective T-type calcium channel modulator, versus placebo in adults with essential tremor (ET) as monotherapy and as add-on…Integrating Multidisciplinary, Family-Centered Care to Optimize Functional Outcomes in Children with Cerebral Palsy.
Objective: Optimal management of Cerebral Palsy requires coordinated, evidence-based interventions that address both motor and non-motor domains across the lifespan. Background: Randomized controlled trials (RCTs)…A Randomized Controlled Trial Evaluating Ankle Pump Combined with Compression Abdominal Belts on Orthostatic Hypotension in Patients with Parkinson’s Disease
Objective: To investigate the short-term efficacy of ankle pump exercise combined with automated compression abdominal belts on orthostatic hypotension (OH) and orthostatic intolerance symptoms in…Acute administration of methylphenidate modulates functional connectivity during the processing of irrelevant stimuli in Parkinson’s disease patients
Objective: Examine the effects of a single dose of methylphenidate (MPD), on event-related functional connectivity (FC), in patients with Parkinson’s disease (PD). Background: Recent studies…An artificial intelligence-based model to predict Parkinson’s disease risk: the AI-PRA study protocol.
Objective: To present the protocol of the Artificial Intelligence-based Parkinson’s Risk Assessment (AI-PRA) study which aims to validate a novel personalised PD risk prediction model…The Registry for Sleep and Circadian Health Quality in Parkinson’s Disease (ReSCQu-PD)
Objective: To assess the feasibility of longitudinal data collection using actigraphy and questionnaires in a clinic-based PD population, characterize the variability of sleep and circadian…Efficacy of Novel Antipsychotic Agents on Cognitive Functions in Parkinson’s Disease: A Systematic Review and Meta-analysis of 2,533 Patients
Objective: To systematically evaluate and quantitatively synthesize evidence on the effects of novel antipsychotic agents (Clozapine, Olanzapine, Risperidone, and Aripiprazole) on cognitive domains in Parkinson’s…Intrafamilial Phenotypic Diversity Associated with Coexisting LRRK2 G2385R and a Novel GCH1 Variant: A Case Report
Objective: To describe intrafamilial phenotypic variability associated with the coexisting LRRK2 G2385R and a novel GCH1 variant in a family presenting with parkinsonism and dystonia…Suicidal Ideation and the Hippocampal Histaminergic System in Huntington’s Disease: A PET Study
Objective: To determine whether presence and severity of suicidal ideation (SI) are associated with hippocampal volume and histamine H3 receptor (H3R) PET uptake in people with Huntington’s disease (PwHD). Background: Suicidal ideation occurs in approximately 8–27% of PwHD, yet its causes remain unclear(1–3). The…Digital Innovation in Parkinson’s Disease – Governing Care and Managing Autonomy
Objective: The study analyzes the regulatory implications of digital technologies in Parkinson’s disease, with particular focus on (1) improvement of care and reduction of intensive…
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