First-in-Human Single-Ascending-Dose Trial of ALN-SNCA, an Intrathecally Administered siRNA for Reducing α-synuclein, in Patients with Early-Stage Parkinson’s Disease
Objective: Development of a Phase 1, First-in-Human (FIH) clinical trial evaluating ALN-SNCA, a novel, intrathecally (IT) delivered small interfering RNA (siRNA) targeting SNCA mRNA to…Prevalence and neuroimaging presentations of Parkinsonism patients with p.R544C NOTCH3 mutation in Taiwan
Objective: To investigate the prevalence and neuroimaging findings of NOTCH3 p.R544C mutation in patients with Parkinsonism in Taiwan. Background: Cerebral autosomal dominant arteriopathy with subcortical…TRACK-PD: Understanding Treatment Routines and Adherence in Care – Knowledge and Perspective of People Living with Parkinson’s Disease
Objective: TRACK-PD aimed to assess adherence behaviors and drivers of treatment interruption/discontinuation from the patient perspective. Background: Treatment adherence is critical in Parkinson’s disease (PD),…Clinical Relevance of Oral Health Assessment in Parkinson’s Disease Monitoring
Objective: To evaluate the clinical relevance of oral health assessment in Parkinson’s disease (PD) by determining whether oral inflammatory, microbial, and periodontal alterations are associated…Burden and Geographic Distribution of Parkinson’s Disease in Mexico: A GBD 2021 Analysis (1990-2023)
Objective: To characterize the burden and geographic distribution of PD in Mexico using Global Burden of Disease (GBD) 2021 data. Background: Parkinson's disease (PD) represents…Altered Motor Regulation and Limbic-Motor Circuits in Paroxysmal Kinesigenic Dyskinesia
Objective: To explore underlying circuit-level mechanisms in paroxysmal kinesigenic dyskinesia (PKD). Background: While the cortico-striato-thalamo-cortical loop and cerebellum are implicated in PKD pathophysiology, the causal…Sleep Disturbances and Dyskinesia Burden in Parkinson’s Disease: Relevance for Motor Complication Management
Objective: To examine if dyskinesia severity, assessed both clinically and using wearable technology, is independently associated with global and domain-specific sleep disturbance in people with…Examining the Impact of Fatigue on White Matter tracts in Parkinson’s Disease
Objective: To determine whether people with Parkinson’s disease (PwPD) with fatigue, and those without fatigue, experience differences in white matter structural connectivity (SC). Background: Fatigue…Brain-targeted dual-loaded extracellular vesicles enable PROTAC-mediated LRRK2 degradation in Parkinson’s disease
Objective: To develop a brain-targeted extracellular vesicle (EV) platform capable of delivering proteolysis-targeting chimeras (PROTACs) across the BBB and inducing degradation of pathogenic proteins in…Task-Dependent Modulation of Reflexive and Voluntary Saccades in Parkinson Disease and Multiple System Atrophy
Objective: The present study aimed to quantitatively compare reflexive and voluntary saccades in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA), and to…
- « Previous Page
- 1
- …
- 95
- 96
- 97
- 98
- 99
- …
- 208
- Next Page »