IPX203 Achieves High Responder Rates Independent of Fluctuation Severity: Insights From RISE‑PD
Objective: To evaluate responder rates for Good ON time and OFF time with IPX203 using PD diary data from the RISE-PD trial, including comparisons by…SMR Combined with Multi Omics to Investigate the Mechanism of Action of the Cell Senescence Associated Gene (CDK2AP1) in Parkinson’s Disease
Objective: To identify novel cellular senescence-related genes in PD using multi-omics, determine causal relationships, predict mechanisms, and validate a key candidate in a rat model.…Logopenic Aphasia After Thalamotomy in Parkinson’s Disease: A Case Report
Objective: To describe a case of acute-onset, progressive language impairment resembling PPA developing after RF thalamotomy in a patient with PD. Background: Primary progressive aphasia…Identification of Digital Measures of Motor Progression from In-Clinic Assessments in Early Parkinson’s Disease for Composite Digital Biomarkers: Results from WATCH-PD
Objective: To identify sensor-based digital measures of motor function that exhibit reliability, association with MDS-UPDRS Part 3, and longitudinal progression in early-stage Parkinson’s disease (PD),…The influence of probable rapid eye movement sleep behavior disorder on PD-related motor and non-motor symptoms and multiple functional outcomes among Chinese community-dwelling elderly population
Objective: To investigate associations of probable REM sleep behavior disorder (pRBD) with Parkinson's disease (PD)-related symptoms and functional outcomes in Chinese older adults. Background: The…Prasinezumab in Early-Stage Parkinson’s Disease: Additional Data from the PADOVA Study
Objective: To evaluate the effect of prasinezumab on delaying disease progression in participants with early-stage Parkinson’s disease (PD) on stable symptomatic medication. Background: Prasinezumab is a humanised IgG1…Activation of the MT1 Receptor Ameliorates Mitochondrial Dysfunction in MPP+/MPTP-Induced Parkinson’s Disease
Objective: This study aimed to explore the role of melatonin receptor 1 (MT1) in improving mitochondrial dysfunction in MPP⁺/MPTP-induced PD models and to clarify the…Longitudinal gait change after unilateral MRgFUS thalamotomy or subthalamotomy in Parkinson’s disease
Objective: To evaluate longitudinal changes in gait parameters in patients with Parkinson’s disease (PD) treated with unilateral Magnetic Resonance-guided Focused Ultrasound (MRgFUS) targeting the ventralis…Testing the body vs brain-first hypothesis in early PD: a cross-sectional study
Objective: To assess whether body vs brain-first PD phenotypes differ in their autonomic, motor and non-motor burden in their early stages. Background: A growing body…Differential Tremor Responses To Transcutaneous Spinal Cord Stimulation Across Tremor Syndromes
Objective: To investigate the effects of transcutaneous spinal cord stimulation (tSCS) in patients with essential and dystonic tremor, and to assess whether baseline spectral regularity…
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