Association between Smoking and LRRK2 Variants on Parkinson’s Disease Risk
Objective: To examine whether smoking modifies the association between protective LRRK2 variants (N551K and R1398H) and the risk of Parkinson’s disease in a case-control cohort.…Subcutaneous Levodopa Infusion in Multiple System Atrophy: a Case Series
Objective: To describe safety, tolerability and clinical response to continuous subcutaneous (SC) levodopa infusion in three patients with multiple system atrophy (MSA). Background: Response to…Machine Learning-Driven Analysis of Epigenetic Signatures in Juvenile Huntington’s Disease: Investigating Histone Modification Dynamics
Objective: To investigate the role of histone modifications in Juvenile Huntington’s Disease (JHD) using machine learning, aiming to identify novel epigenetic biomarkers predictive of disease…Impact of Hula on Balance Outcomes in Parkinson’s Disease
Objective: This study aims to determine the impact of a 12-week Hula program on balance in patients with Parkinson’s Disease (PD) and to investigate changes…Caffeine and Tobacco Exposure and the Presence of Levodopa-Induced Dyskinesia (LID) in the STAT-PD Trial
Objective: Using data from the STAT-PD trial, ClinicalTrials NCT # 4064294, we examined whether lifetime caffeine and nicotine exposure are associated with the presence and…Levodopa-induced peak-dyskinesia and motor fluctuations in corticobasal syndrome
Objective: Describe two corticobasal syndrome (CBS) cases presenting with levodopa-induced dyskinesia (LID), one with motor fluctuations (MFs). Background: CBS is a rare neurodegenerative syndrome characterized…Brain Atlas-Based Machine Learning for Parkinsonian Disorders Classification and Evaluation of Classification Performance Across Disease Duration
Objective: To evaluate the diagnostic performance of a multi-atlas MRI–based machine learning model for differentiating degenerative parkinsonian disorders and to examine how classification accuracy varies…Effect of ApoE ε4 allele on brain metabolism and cognition in non-demented Parkinson’s disease
Objective: This study aimed to explore the interplay between Apolipoprotein E (ApoE) ε4 allele, brain metabolism, and cognition in non-demented Parkinson’s disease (PD) patients. Background:…18F-FD4 PET Reveals α-Synuclein Deposition and Clinical Correlations in Parkinson’s Disease
Objective: This study aimed to determine the potential of a novel α-syn tracer, 18F-FD4 PET, to track regional α-synuclein deposition in PD and explore its…Incidence and Outcomes of Hip Fractures in Parkinsonism vs Non-Parkinson Population: A Systematic Review of the Literature
Objective: To assess hip fractures incidence in Parkinsonism patients and assess their outcome. Background: Parkinson's disease is associated with gait disturbance, postural instability, and increased…
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