Lack of Toll-like receptor 4 is associated with accumulation of alpha-synuclein in the midbrain Parkinson’s disease mice.
Objective: In this study we aimed to investigate the potential role of Toll-like receptor 4 (TLR4) in mediating both the dopaminergic neuron loss and alpha-synuclein (alpha-SYN)…SCFAs participate in the pathogenesis of Parkinson’s disease by regulating NLRP3 inflammasomes activation
Objective: To explore the role and related mechanism of gut microbiota metabolites short-chain fatty acids(SCFAs) in the pathogenesis of Parkinson's disease(PD). Background: Growing research have…Pharmacological activation of Rev-erbα Provides Neuroprotection against Parkinson’s Disease
Objective: In this study, we investigated the effects of SR9009, a Rev-ERB agonist, on the dopaminergic system in the MPTP model of PD. Background: Circadian…Effects of fine particulate matter and cigarette smoking on MPTP-induced dopaminergic neuronal cell death: Implication for Parkinson’s disease
Objective: The objective of this study was to determine the potential neurotoxicity of fine particulate matter (FPM) and the neuroprotective properties of nicotine in the pathogenesis…The Role Imposed by The High-Mobility Group Box 1 (HMGB1) Protein in MPTP-Induced Zebrafish Model of Parkinson’s Disease
Objective: This study aims to investigate the role of HMGB1 protein in mediating neuroinflammatory-induced parkinsonian movement disorder of the MPTP-induced zebrafish model of Parkinson's disease…Technology use in Parkinson’s disease and parkinsonism: a multicenter survey in real-life Healthy East Lombardy Parkinson (HELP-)network
Objective: to evaluate the real-life use of internet and technological devices in parkinsonian patients Background: technology use is increasing in the ageing population but no…Calcitriol Treatment Attenuates Dopaminergic Neurodegeneration in Mice Model of Parkinson’s Disease
Objective: To investigate the role and mechanism of Calcitriol (1,25-dihydroxyvitamin D3) in Parkinson's mice and cell model Background: Parkinson's disease (PD) is a neurodegenerative disorder…Long-term effect of deep brain stimulation in a monkey model of Parkinson’s disease with L-Dopa–induced dyskinesias
Objective: This study investigated the effect of long-term deep brain stimulation (DBS) of the subthalamic nucleus (STN) on motor behavior in a parkinsonian monkey treated…Compared the effects of probiotics and Anti-PD particles on the behavior of Parkinson’s disease mice model
Objective: To compared the effects of probiotics and Anti-PD particles on the behavior of mice with MPTP Parkinson's disease (PD) model. Background: Intestinal flora may…Abrogation of neuroinflammation and behavioural deficit by Chlorogenic acid and Tinosporia cordiofolia in MPTP-Induced Parkinsonian mice model via suppressing NF-κB pathway
Objective: The current study was designed with the aim to investigate the anti-neuroinflammatory activity of chlorogenic acid (CGA) and ethanolic extract of Tinospora cordifolia (TPE)…
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