Protective effect of anodal transcranial direct current stimulation on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via modulating mitochondrial dynamics
Objective: The present study elucidated the neuroprotective effects of tDCS on the mitochondrial quality control pathway in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model. Background: Abnormal…Hydralazine protects nigrostriatal dopaminergic neurons from MPP+ and MPTP induced neurotoxicity: Roles of Nrf2-ARE signaling pathway
Objective: In this study, we tested whether hydralazine can attenuate 1-Methyl-4-phenylpyridinium (MPP+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced neurotoxicity in vitro and in vivo by activating Nrf2…Inhibition of mitochondrial complexes induces unique transcriptomic and epigenetic profiles: implications to neurodegeneration induced movement disorders
Objective: To compare the neurotoxicological hallmarks induced by inhibitors of mitochondrial complex I (CI- 1- methyl-4- phenylpyridinium; MPP+), complex II (CII- 3- nitropropionic acid; 3-…THE EXPRESSION OF INOS IN MOUSE EXPERIMENTAL MODEL POINTS TO INFLAMMATORY CONDITIONS ASSOCIATED WITH PARKINSON’S DISEASE
Objective: The objective of conducting this study was to evaluate the expression of iNOS in mouse experimental model of PD. Background: Parkinson’s Disease (PD) is…Beneficial and protective effects of Terminalia chebula in a murine model of Parkinson’s disease
Objective: Present study was designed to investigate whether Terminalia chebula (TC) extract would prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced neurotoxicity in male Wistar rats. Background: Parkinson's disease (PD)…Increased vesicular monoamine transporter alleviate MPTP-induced impairment of neurogenesis
Objective: In this study, we employed vesicular monoamine transporter 2–overexpressing mice (VMAT2-HI) to investigate the influence of increased vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced…Improving neuroprotective effects of resveratrol by brain targeting through chitosan glutamate nanoparticles in MPTP induced parkinsonism
Objective: The aim of the present study was to develop and evaluate the neuroprotective effects of resveratrol (RV) using chitosan glutamate nanoparticles (RV-CG-NPs) in a…Apigenin loaded Phospholipid based nanoemulsion in Therapeutics of Parkinson’s Disease Via Attenuation of Oxidative Stress and Upregulation of Dopamine.
Objective: The aim of the present study was to develop, optimizes and evaluate the antiparkinson effects of apigenin loaded phospholipid based nanoemulsion via attenuation of…The Nigeria Parkinson Disease Registry
Objective: To describe the methodology and preliminary baseline data from the Nigeria Parkinson Disease Registry (NPDR). Background: Disease registries offer an opportunity to expand the…Oral treatment with sphingosine-1-phosphate receptors modulator prevents Parkinson symptoms concomitantly to reduced brain inflammation in MPTP mouse models
Objective: Here we explore the efficacy of an oral treatment with Fingolimod (FTY720), a selective sphingosine-1-phosphate receptors modulator, to prevent MPTP induced nigrostriatal loss and…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.