Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: Present study was designed to investigate whether Terminalia chebula (TC) extract would prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced neurotoxicity in male Wistar rats.
Background: Parkinson’s disease (PD) is a major neurological disorder known since ancient times. It is characterized by signs of major oxidative stress and mitochondrial damage in the pars compacta of substantia nigra.
Method: MPTP was stereotaxically injected into the substantia nigra pars compacta of male Wistar rats. Male Wistar rats were divided into following five groups: Group I received vehicle (saline (10 ml/kg for 21 days) orally); Group II received TC extract (200 mg/kg for 21 days) orally; Group III was treated with 20 mg/kg MPTP i.p. for 21 days; Group IV received 20 mg/kg MPTP, i.p. along with 200 mg/kg TC orally for 21 days. Group V received 20 mg/kg MPTP i.p. along with 400 mg/kg TC orally for 21 days. And then, the rats were sacrificed for further studies.
Results: The mice treated with MPTP developed motor dysfunction and behavioral alterations similar to PD, which was tested with rotarod test, and hang test which revealed the impaired performance, working memory, object recognition, reduced neurogenesis and impaired neuromuscular strength respectively. Group III rats elicited significant increase in lipid peroxidation along with reduction in level of antioxidant enzymes and total antioxidants. Histological data revealed that MPTP treated rats shown pathological changes like cellular inflammation and vascular degeneration in brain tissue. Treatment with TC extract reversed the motor dysfunction, antixodant enzymes, lipid peroxidation significantly in a dose dependent manner. The Bcl-2/Bax gene expression ratio and protein expression of brain derived neurophic factor (BDNF) were significantly increased in TC treated groups.
Conclusion: TC by its antioxidant property has a neuroprotective activity both in motor activity and behaviourally in the MPTP induced Parkinson disease in mice.
To cite this abstract in AMA style:
A. Kumar, S. Farhat. Beneficial and protective effects of Terminalia chebula in a murine model of Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/beneficial-and-protective-effects-of-terminalia-chebula-in-a-murine-model-of-parkinsons-disease/. Accessed May 13, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/beneficial-and-protective-effects-of-terminalia-chebula-in-a-murine-model-of-parkinsons-disease/