Partial depletion of peripheral M1 macrophages ameliorates the neuroinflammation and dopaminergic neuronal death in the brain of a MPTP-induced mouse model of PD
Objective: Neuroinflammation in the PD brain involves the activation of microglia and the increasing levels of inflammatory cytokines. Several studies have shown that the peripheral…Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice
Objective: We hypothesize that cerebral hypoperfusion may influence the cognitive function of PD animal models. To investigate the effects of cerebral hypoperfusion and microangiopathy on…Neuroprotective role of Tinospora cordifolia in MPTP induced Parkinsonian mouse model
Objective: To evaluate the neuroprotective effect of Tinospora cordifolia aqueous extract (TCAE) in Parkinsonian mice. Background: Parkinson’s disease, an age related neurodegenerative disorder, is characterized…Novel mechanistic involved in targeting Parkinsons Disease by Indolocarbazole derivatives as inhibitors against Cyclin Dependent kinases using molecular modelling and simulation approaches
Objective: To validate effect of Indolocarbazole derivatives on Cyclin dependent kinase for treating Parkinson's (Preliminary work in context of CDK5 assay and Simulations have been…Neuroprotective Potency of Tetrahydroisoquinoline a Novel Ayurveda Molecule in Experimental Parkinson’s Disease
Objective: Tetrahydroisoquinoline (TIQ) an identified alkaloid from ancient Indian ‘Ayurveda’ medicine for Parkinson’s disease (PD) was tested for neuroprotection in a cellular system and a…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…Interaction between PLK2 ( Polo-like kinase-2) and alpha-synuclein in the non-human primate MPTP model of Parkinson disease
Objective: The objective is to determine the levels and interactions between PLK2 and one of its main substrates, synuclein, in the non-human primate MPTP model of…Neuroprotective effect of α-Mangostin in restoration mitochondrial function in MPTP-Induced Parkinson’s disease in mice
Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice. Background: It…Neuroprotection and Alleviation of Parkinsonian Phenotypes by Ayurvedic Herbs
Objective: Our laboratory has focused on the herbal treatment of Parkinson’s disease especially by the above two common herbs Withania somnifera (Ws) and Mucuna pruriens…Piperine potentiate the neuroprotective effect of quercetin against MPTP induced neurotoxicity in rats
Objective: (1) Quercetin is well tolerated bioflavonoid used as supplement for various disorders but problem is its low oral bioavailability and (2) Piperine is combined…
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