Association of Increased Frontal White Matter A2A Receptor Availability with Decreased Frontal Gray Matter Volume in Patients with Parkinson’s Disease
Objective: We sought to investigate in vivo changes in A2A receptor availability in cerebral white matter of PD patients and its association with gray matter…Decreased Availability of Adenosine 2A Receptors in the Caudate in Patients with Early Stage Parkinson’s Disease
Objective: The aim of this study was to investigate Adenosine 2A (A2A) receptor availability in patients with early and moderate stage Parkinson’s disease (PD). Background:…Pharmacological investigation of biochemical and behavioral effects resembling Huntington’s disease utilizing selective calcium and calmodulin dependent phosphodiesterase inhibitor
Objective: To investigate the effects of selective phosphodiestrase (PDE) inhibitors in Nimodipine induced neuro degeneration (animal models of Huntington’s disease) in rats. Background: Nimodipine is…Design and discovery of 1,2,4 triazole derivatives as adenosine A2A receptor antagonist against parkinson’s disease
Objective: In the present study, we intended to develop novel 1,2,4 triazole as potent A(2A)AR antagonists against parkinson’s disease. Background: Parkinson’s disease (PD) is a…Istradefylline and Preladenant as adjuvant therapies for Patients with Parkinson’s disease
Objective: The aim of this meta-analysis is to synthesize evidence about the efficacy of the adenosine receptor antagonists (Istradefylline and Preladenant) for patients with Parkinson’s…Clinical efficacy of istradefylline on lower urinary tract symptoms in Parkinson’s disease: A prospective study
Objective: The aim of the present study was to determine the effects of istradefylline, adenosine A2A receptor antagonist on lower urinary tract symptoms (LUTS) in…Anxiolytic-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) in rodent models of anxiety
Objective: The aim of this study was to assess the anxiolytic effects of istradefylline (KW-6002), an adenosine A2A receptor antagonist, in naive and anxiety-prone animals…Efficacy of long-term treatment with istradefylline and analysis of the expression of A2A receptor protein and post-transcriptional DNA methylation
Objective: To evaluate the pharmacological properties of Adenosine A2A receptor antagonist, istradefylline (IST), and analyze A2AR protein levels of peripheral lymphocytes and the frequency of…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.