Segment-Level Gait Dynamics Reveal Parkinsonian Motor Signatures in Fall-Prone Older Adults Using Multi-Channel Time–Frequency Deep Learning
Objective: To develop a multi-channel time–frequency deep learning framework capable of identifying Parkinsonian gait dynamics from short locomotor segments and detecting PD-like motor state transitions…Machine Learning–Based Brain Age Modeling Reveals Accelerated Structural Degeneration in Parkinson’s Disease
Objective: To compare the rate of global brain structural degeneration between healthy controls (HC) and patients with Parkinson’s disease (PD). Background: Normal aging is accompanied…Improving Equitable Access to Parkinson’s Disease Exercise Programs Through a Student-Led Transportation Model
Objective: To evaluate the feasibility and impact of a student-led transportation model designed to improve access to evidence-based exercise programs for people with Parkinson’s disease…Clinical Factors Associated with the Hospitalization of Patients with Parkinson’s Disease: A 3-year Prospective Study
Objective: This prospective study investigated the clinical factors associated with the hospitalization of patients with Parkinson’s disease (PD). Background: Patients with PD have higher hospitalization…Interpretable AI for Quantitative Video-Based UPDRS Assessment of Hand Movements in Parkinson’s Disease
Objective: To quantify and compare the diagnostic contributions of the three standard MDS-UPDRS hand motor tasks using video-based assessment of bradykinesia in Parkinson's Disease (PD).…SIRT3 upregulation in nigral dopaminergic neurons preserves motor circuit integrity for anti-sarcopenia
Objective: To determine whether enhancing resilience of substantia nigra dopaminergic neurons preserves motor circuit integrity. Background: Degeneration and dysfunction of substantia nigra pars compacta (SNpc)…A Patient-Directed AI-Enabled Platform for Continuous Personalised Parkinson’s Management
Objective: To describe the co-design and staged evaluation of a novel AI-enabled digital health platform for Parkinson’s where structured patient and clinician feedback informs iterative…Sex Differences in Motor and Nonmotor Symptoms of De Novo Parkinson Disease by Age Group
Objective: While sex differences in Parkinson's disease (PD) are widely reported, data on how age influences these clinical variations are scarce. It is not fully…Efficacy of Mechanoacoustic Vibration Therapy on Motor Function, Bone Density, and Sleep Architecture in Elderly Women with Restless Legs Syndrome
Objective: To evaluate the rehabilitative impact of targeted mechanoacoustic vibration therapy on mobility, bone mineral density (BMD), pain, and sleep quality in elderly women with…SMR Combined with Multi Omics to Investigate the Mechanism of Action of the Cell Senescence Associated Gene (CDK2AP1) in Parkinson’s Disease
Objective: To identify novel cellular senescence-related genes in PD using multi-omics, determine causal relationships, predict mechanisms, and validate a key candidate in a rat model.…
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