SIRT3 upregulation in nigral dopaminergic neurons preserves motor circuit integrity for anti-sarcopenia
Objective: To determine whether enhancing resilience of substantia nigra dopaminergic neurons preserves motor circuit integrity. Background: Degeneration and dysfunction of substantia nigra pars compacta (SNpc)…A Patient-Directed AI-Enabled Platform for Continuous Personalised Parkinson’s Management
Objective: To describe the co-design and staged evaluation of a novel AI-enabled digital health platform for Parkinson’s where structured patient and clinician feedback informs iterative…Sex Differences in Motor and Nonmotor Symptoms of De Novo Parkinson Disease by Age Group
Objective: While sex differences in Parkinson's disease (PD) are widely reported, data on how age influences these clinical variations are scarce. It is not fully…Efficacy of Mechanoacoustic Vibration Therapy on Motor Function, Bone Density, and Sleep Architecture in Elderly Women with Restless Legs Syndrome
Objective: To evaluate the rehabilitative impact of targeted mechanoacoustic vibration therapy on mobility, bone mineral density (BMD), pain, and sleep quality in elderly women with…SMR Combined with Multi Omics to Investigate the Mechanism of Action of the Cell Senescence Associated Gene (CDK2AP1) in Parkinson’s Disease
Objective: To identify novel cellular senescence-related genes in PD using multi-omics, determine causal relationships, predict mechanisms, and validate a key candidate in a rat model.…Cerebrospinal Fluid Markers are associated with Cognitive Decline in GBA1-associated Parkinson’s Disease
Objective: To analyze whether and how cerebrospinal fluid (CSF) amyloid-related markers relate to the longitudinal cognitive profile in PD-GBA1. Background: Cognitive decline in Parkinson’s disease…Cell-type-specific asynchronous aging acceleration across movement disorders
Objective: To quantify brain cell-type–specific biological aging across different movement disorders (MDS) and compare similarities and differences in cellular aging patterns among MDS. Background: It…Digital Speech Biomarkers Reveal Speech Changes in Physiological Aging and Parkinson’s Disease
Objective: This study investigates speech characteristics associated with physiological and pathological aging, using Parkinson’s disease (PD) as a model, with the aim of identifying linguistic…Loss of NAA60-mediated N-terminal acetylation cause primary brain calcification with disturbed Golgi- and phosphate-maintenance functions
Objective: Our ongoing study describes new NAA60-PBC cases, functionally characterizes additional NAA60 protein variants and investigates the cellular mechanisms underlying NAA60-PBC. Background: NAA60 is a…Characteristics and Outcomes of Hospitalisation Episodes for Australians living with Parkinson’s Disease
Objective: To examine the characteristics and outcomes of acute inpatient hospitalisation episodes for people with Parkinson’s disease (PD) living in Victoria, Australia. Background: People with…
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