The effect of anti- Parkinson’s disease granules and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine -induced Parkinson’s disease
Objective: To investigate the effect of anti- Parkinson’s disease (anti-PD granules) and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine( MPTP )-induced PD. Background:…Selegiline drives autophagic secretion of α-synuclein
Objective: Our aim is to elucidate how selegiline drives extracellular secretion of α-synuclein (αS) and whether selegiline-induced αS secretion affects cell-to-cell transmission of αS. Background:…In vitro α–synuclein aggregation and propagation model
Objective: Developing an in vitro α–synuclein (α-s) aggregation and propagation model of human cortical networks for functionality studies. Background: Studying α–s pathology and its effects…The contribution of Brain Bank for Aging Research to pathomechanism of Parkinson’s disease
Objective: Objective: The aim of this paper is to present the result of the whole body screening of Lewy body pathology by Brain Bank for…The role of RNA-carrying exosomes in synaptic physiology and in synucleinopathies
Objective: Our goals were: (i) to characterize the molecular mechanisms associated with the transfer of miRNAs from astrocytes to neuronal synapses via exosomes in transgenic…Impact of the severity of Parkinson’s disease on skin elasticity
Objective: To investigate changes in skin elasticity according to the severity of symptoms of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease caused…Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson’s disease: A Systematic Review and Network Meta-Analysis
Objective: We performed meta-analysis to determine the diagnostic and differential diagnostic value of α-syn SAAs for PD, and to investigate the optimal specimens. Background: Alpha-synuclein…Peripheral Synucleinopathy in Essential Tremor Plus Patients with Parkinsonian Features and Normal Dopamine Transporter Imaging
Objective: To describe results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) in patients with essential tremor (ET) with parkinsonism. Background: Patients with longstanding ET may…A staged screening paradigm to identify people at risk of Parkinson’s disease in the Parkinson’s Progression Markers Initiative
Objective: To identify people at risk of Parkinson’s disease (PD) using a staged-screening paradigm. Background: Early recognition of people with PD may be essential to…Decreased α-synuclein membrane-binding in the enteric nervous system as a marker of early pathology in Parkinson’s disease
Objective: The goal is to measure α-Synuclein (αSyn) membrane-binding in the enteric and central nervous system in Parkinson’s disease (PD) using both a novel, humanized…
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