Multidimensional phenotyping of human stem cell-derived midbrain dopaminergic neurons from a SNCA triplication carrier for drug screening applications
Objective: We hypothesized that combining multiple Parkinson's disease (PD) relevant cellular phenotypes will increase the accuracy, stability, and usability of human midbrain dopaminergic (mDA) neuronal…Genetic stratification of motor and quality of life outcomes in Parkinson’s disease in the EARLYSTIM study
Objective: We identified (Weiss et al., 2016) that single nucleotide polymorphism (SNPs) of the alpha-synuclein gene (SNCA) predicted the motor effect of subthalamic nucleus stimulation (STN-DBS)…Phosphorylated α-synuclein at serine residue 129 decreased in Parkinson’s disease patients taking 250mg of daily niacin for six months
Objective: The main objective was to determine if α-synuclein could be modulated by niacin supplementation, contributing to improved Parkinson’s disease (PD) symptoms. Background: Niacin supplementation…The role of GBA1 mutations in the relationship between GBA1 and alpha-synuclein in Parkinson disease
Objective: The aim of the study was to understand how the E326K GBA1 mutation results in an increased risk for Parkinson disease, through influencing the…Lack of Toll-like receptor 4 is associated with accumulation of alpha-synuclein in the midbrain Parkinson’s disease mice.
Objective: In this study we aimed to investigate the potential role of Toll-like receptor 4 (TLR4) in mediating both the dopaminergic neuron loss and alpha-synuclein (alpha-SYN)…Oligomeric alpha-synuclein in reflex tears and retinal changes in Parkinson’s disease
Objective: To compare oligomeric alpha-synuclein (α-Syn) in reflex tears and its association with the thickness of retinal layers in Parkinson’s disease (PD) Background: Alpha-synuclein is…Utility of Seed Amplification Assay for Detecting α-synuclein in Formalin-Fixed Paraffin Embedded Skin Samples in Parkinson’s Disease
Objective: To determine the sensitivity for Parkinson’s disease (PD) diagnosis of seed amplification assay (SAA) for α-synuclein (α-syn) in formalin-fixed paraffin-embedded (FFPE) skin specimens and…APEG-PCL Nanoparticles Containing Rifampicin Target Dopaminergic Neurons to reduce α-synuclein aggregation
Objective: There were accumulating evidence proving that rifampicin could protect neurons from apoptosis in Parkinson's disease in-vitro model by regulating SUMO modification of α-synuclein. However,…Autonomic dysfunction and its correlation witn synucleinopathy: an immunohistological study in Tunisian patients with parkinson disease
Objective: Identify autonomic digestive symptoms of Parkinson disease (PD)Identify correlations between autonomic dysfunction and alpha-synuclein immunochemical staining in the upper digestive tract. Background: Pathological processes…Blood microRNA-7 as a Progression Biomarker in Parkinson’s disease
Objective: This study investigates the use of microRNA-7-5p (miR-7-5p) as a potential biomarker for Parkinson’s disease (PD) progression. Background: MiR-7-5 is a microRNA that regulates…
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