Spreading ɑ-synuclein pathology initiated from the sublaterodorsal tegmental nucleus models RBD followed by Parkinsonian phenotypes in mice
Objective: To recapitulate ɑ-synucleinopathy based RBD-like behaviors in mice which could further proceed to develop Parkinsonian behavioral and histopathological phenotypes. Background: Idiopathic REM sleep behavior…GCI-induced neurodegeneration and synucleinopathy in non-human primates
Objective: This study aimed at determining the potential to induce MSA pathology in non-human primates. Background: Aggregation of alpha-synuclein has been implicated in several neurodegenerative…Blood alpha-synuclein profile and lysosomal alterations distinguish GBA1-related Parkinson’s disease from sporadic Parkinson’s disease
Objective: This study aims to characterize blood profile of alpha-synuclein and the main lysosomal proteinsas well as clinical features of PD subjects carrying GBA1 mutations…Protective role of astrocytes on α-synuclein accumulation and propagation
Objective: This study is aimed to investigate the role of astrocytes on the accumulation and propagation of α-synuclein (a-syn), the main component of Lewy bodies/neurites,…Mixed pathologies in pancreatic beta-cells from subjects with neurodegenerative diseases and their interaction with prion protein
Objective: We studied whether, as in the brain, pancreatic -cells of subjects with neurodegenerative diseases also present co-occurrence of other misfolded proteins. Furthermore, we also assessed…The effect of comorbid NPH on the clinical feature and progression of Parkinson’s disease
Objective: To analyze the effect of co-existing normal pressure hydrocephalus (NPH) on the clinical course of Parkinson's disease (PD), we examined the disease progression and…Characterizing the genetic architecture of Parkinson’s disease in Latinos
Objective: By performing the first genome-wide association study (GWAS) of Parkinson’s disease (PD) in Latinos, we seek to interrogate the genetic architecture of PD in…Detection of alpha-synuclein aggregation from submandibular and esophageal tissue of patients with synucleinopathies
Objective: Utilize cyclic amplification methods to facilitate detection of aggregation prone forms of a-syn from submandibular or esophageal tissue of patients with syncleinopathies. Background: In…Alpha synuclein BAC transgenic mice as a preclinical model for disease-modifying therapies in Parkinson’s disease
Objective: The aim of this study is to make preclinical mice models for disease-modifying therapies in Parkinson's disease. Background: The prodromal stage of Parkinson's disease…Microbiome from Parkinson’s patients shows an increase in polyamines metabolism and differentially expresses microbial bacterial taxa compared to aged-matched normal controls
Objective: The goal of this study was to determine whether the microbiome from Parkinson’s disease (PD) has alterations in a) Polyamine metabolism and b) Expressed…
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