Prevalence of orthostatic hypotension and postprandial hypotension in neurodegenerative diseases with synucleinopathy: a systematic review and meta-analysis
Objective: This study aimed to evaluate the prevalence of orthostatic hypotension (OH) and postprandial hypotension (PPH) in patients with Parkinson's disease (PD), multiple system atrophy…Are we underestimating the dysautonomic burden in GBA related a-synucleinopathies?
Objective: The aim of the present study is to understand the prevalence of dysautonomic symptoms in a cohort of Italian glucocerebrosidase (GBA) mutated patients with…Dissecting the genetic complexity of Parkinson’s disease: a Parkin-GBA study
Objective: In this study, we investigate how the PD risk factor GBA would affect the cellular phenotypes associated with homozygous mutations in Parkin, causing an…A Study of Microglial Metabolism in Neuroinflammation
Objective: Targeting of microglial metabolism may be a potential therapeutic option for diseases such as PD [Parkinson’s Disease] and LBD [Lewy Body Dementia]. To establish…Serum uric acid level as a biomarker in sporadic and familial (p.A53T alpha synuclein carriers) Parkinson’s disease: Longitudinal data from the PPMI study
Objective: To determine whether there are longitudinal differences in serum uric acid level among sporadic Parkinson’s disease (PD) patients, PD patients harboring the p.A53T mutation…Analysis of brain-derived blood exosomes for diagnostics of synucleinopathies
Objective: Here, we aimed to determine if measuring of α-synuclein concentration in these vesicles from oligodendrocytes and neurons can distinguish between patients with MSA or…11C-PBB3 PET in PD: does alpha-synuclein pathology start in axonal terminals?
Objective: To use 11C-PBB3 PET binding to monitor alpha-synuclein (a-syn) pathology in PD subjects in vivo. Background: In previous work we have shown binding of…Methylation status of SNCA gene in patients with Parkinson disease in Russian population
Objective: To study methylation status of SNCA gene in patients with Parkinson disease in Russian population Background: The genetic background of Parkinson disease (PD) has…Automated Immunohistochemical Detection of Skin Depositions of Pathological alpha-Synuclein in Idiopathic REM Sleep Behavior Disorder and Parkinsonism
Objective: The goal of this study was to employ a novel highly sensitive dual-stain immunohistochemical (IHC) assay in the assessment of cutaneous pathological alpha-synuclein (aSyn)…CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
Objective: Activated microglia and increased cytokine levels could precede neurodegeneration in neuro-inflammation in A53T mice, and CXCL12 was found increased in plasma CNS-derived exosomes, which…
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