Basal Ganglia Pathway Recruitment Determines Bidirectional Bradykinesia Modulation by DBS in Humans
Objective: Understanding the role of distinct basal ganglia pathways in DBS-elicited modulation of bradykinesia across its indications. Background: Opposing bidirectional effects of selective pathway stimulation…Digital Kinematic Measures of Finger Tapping Detect Dose-Dependent Effects of Deep Brain Stimulation in Parkinson’s Disease
Objective: To evaluate whether video-based digital kinematic measures can quantify dose-dependent changes in finger tapping performance during deep brain stimulation (DBS) in Parkinson’s disease. Background:…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Differential effects of levodopa and subthalamic nucleus deep brain stimulation on the bradykinesia components in Parkinson’s Disease
Objective: To quantify and compare the differential effects of DBS and L-dopa on the individual kinematic components of bradykinesia. Background: Parkinson’s disease (PD) bradykinesia is…Can Prayer Beads Quantify Bradykinesia? An Ultra-Low-Cost Approach to Motor Assessment in Parkinson’s Disease
Objective: To explore the potential use of portable mechanical counters as a simple approach to quantifying finger movement activity in the evaluation of bradykinesia. Background:…Microstructural Correlates of Parkinson’s Bradykinesia
Objective: Define the microstructural correlates of bradykinesia in Parkinson’s disease. Background: Bradykinesia is defined as “slowness of movement”, often associated with decrement, and linked to…Mild Motor Impairments in Rapid Eye Movement Behavior Disorder: Tremor and Bradykinesia
Objective: We investigated patients with RBD to identify mild motor impairments through the objective quantification of sensitive motor control assays. Background: It is established that…Characterizing Longitudinal Motor Progression in Parkinson’s Disease leveraging Digital Health Technologies in L-DOPA ON and OFF States
Objective: To characterize the longitudinal motor progression of Parkinson’s disease (PD) over 104 weeks both in practically defined on and off medication states using a…An artificial intelligence-based model to predict Parkinson’s disease risk: the AI-PRA study protocol.
Objective: To present the protocol of the Artificial Intelligence-based Parkinson’s Risk Assessment (AI-PRA) study which aims to validate a novel personalised PD risk prediction model…Motor variability in isolated and probable REM sleep behaviour disorder using remote finger tapping
Objective: To determine whether motor impairment and variability extend from isolated REM sleep behaviour disorder (iRBD) to probable RBD (pRBD), and whether instability can be…
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