Feasibility and Efficacy of Brainstem Modulation Therapy for the Management of Parkinson’s Disease
Objective: To evaluate the feasibility and potential efficacy of a software-controlled, solid-state caloric vestibular stimulation (CVS)-mediated brainstem modulation device for the treatment of non-motor and…AAV-mediated human alpha synuclein overexpression in the locus coeruleus (LC) leads to a neuronal loss in the nucleus ambiguus of mouse.
Objective: To investigate the impact and temporal aspects of the neuronal loss in the LC neurons induced by alpha-synucleinopathy Background: In the Braak staging model…Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – a preclinical model of Parkinson’s disease
Objective: In our present study, we developed a new mouse model to study the time dependent effects of cellular A53T-α-synuclein overexpression in the locus coeruleus,…Epilepsy and Cranial nerve affection in a Patient with Wilson’s disease and Intracranial developmental venous anomaly; A Case Report
Objective: 1.present unusual and rare clinical presentations in the disease spectrum2.study Intracranial developmental venous anomalies (DVAs) presentations both clinically and radiologically in Wilson’s disease and their…Towards Responsive Deep Brain Stimulation for Medically Refractory Freezing of Gait in Parkinson’s Disease
Objective: Medically refractory FoG presents an unmet and pressing need to develop novel therapeutic strategies. We seek to describe the electrophysiology of the pedunculopontine nucleus…Magnetic resonance diffusion tensor imaging for the pedunculopontine nucleus: Correlation between neuroimaging and cytoarchitectonic features
Objective: We investigate DTI and Fractional Anisotropy maps both in vivo and in post-mortem MR studies. In situ imaging findings were correlated with those obtained…Inhibition of nociceptive responses by modulating serotonergic signals at the rostral ventromedial medulla in 6-OHDA-induced Parkinson’s disease rat model
Objective: We aimed to determine whether the descending 5-HT facilitatory pathway from rostral ventromedial medulla (RVM) and the extracellular 5-HT in RVM are involved in…Cortical role in the freezing of gait in Parkinson’s disease
Objective: In this study, we aimed to investigate the neural underpinning of freezing of gait (FOG) in Parkinson's disease (PD), especially the role of the…Detecting brainstem changes in Parkinson’s disease using quantitative MRI
Objective: 1. Can brainstem changes be detected using quantitative MRI (qMRI). 2. How many subjects would be required to detecting changes in brainstem regions affected…Striatal and pedunculopontine nucleus diffusion tensor imaging in cervical dystonia
Objective: To characterize white matter integrity in the striatum and pedunculopontine nucleus (PPN) in patients with cervical dystonia using diffusion tensor imaging (DTI). Background: The…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.